摘要
目的观察补中益气五苓汤联合卡维地洛治疗老年慢性心力衰竭的临床疗效。方法选择2018年4月至2019年4月西安市中医医院收治的100例老年慢性心力衰竭患者作为研究对象,采用随机数表法分为观察组和对照组各50例。对照组采用卡维地洛治疗,观察组在此基础上联合补中益气五苓汤治疗。治疗10周后比较两组患者的治疗效果、治疗前及治疗10周后的中医证候积分、血浆N端脑钠肽(NT-proBNP)水平、左射血分数(LVEF)、左室舒张末期内径(LVEDD)、右心室收缩末期(LVESD)变化和不良反应。结果观察组患者的治疗总有效率为94.0%,明显高于对照组的78.0%,差异有统计学意义(P<0.05);治疗后,两组患者的中医证候积分、NT-proBNP水平明显降低,且观察组[(5.10±0.98)分、(518.13±18.41) pg/mL]明显低于对照组[(8.29±1.52)分、(658.39±20.14) pg/mL],差异均有统计学意义(P<0.05);治疗后,两组患者的LVEDD、LVESD明显降低,且观察组[(45.19±3.97) mm、(37.13±3.68) mm]明显低于对照组[(50.13±4.27) mm、(43.52±4.27) mm],而LVEF明显升高,观察组为(49.10±4.18)%,明显高于对照组的(42.52±3.69)%,差异均有统计学意义(P<0.05);观察组和对照组患者治疗期间的总不良反应发生率比较差异无统计学意义(P>0.05)。结论补中益气五苓汤联合卡维地洛治疗老年慢性心力衰竭疗效良好,其可有效改善患者的临床症状和心功能,值得临床推广应用。
Objective To observe the clinical efficacy of Buzhong Yiqi Wuling Decoction combined with carvedilol in the treatment of elderly chronic heart failure.Methods A total of 100 elderly patients with chronic heart failure admitted to Xi'an Hospital of Traditional Chinese Medicine from April 2018 to April 2019 were selected and divided into the observation group and control group according to random number table method,with 50 patients in each group.The control group was treated with carvedilol,and the observation group was treated with Buzhong Yiqi Wuling Decoction on this basis.After 10 weeks of treatment,the treatment effects of the two groups,including TCM syndrome scores before and after 10 weeks of treatment,plasma N-terminal brain natriuretic peptide(NT-proBNP)levels,left ejection fraction(LVEF),left ventricular end diastole internal diameter(LVEDD),right ventricular end systole(LVESD)changes and adverse reactions were compared.Results The total effective rate of treatment in the observation group was 94.0%,which was significantly higher than 78.0%in the control group(P<0.05).After treatment,TCM syndrome score and NT-proBNP of both groups decreased,and those in the observation group were(5.10±0.98)points,(518.13±18.41)pg/mL,significantly lower than(8.29±1.52)points,(658.39±20.14)pg/mL in the control group(P<0.05);LVEDD and LVESD of both groups decreased,and those in the observation group were(45.19±3.97)mm,(37.13±3.68)mm,significantly lower than(50.13±4.27)mm,(43.52±4.27)mm in the control group(P<0.05);LVEF increased,and that in the observation group was(49.10±4.18)%,significantly higher than(42.52±3.69)%in the control group(P<0.05);there was no significant difference in the incidence of total adverse reactions between the observation group and the control group(P>0.05).Conclusion Buzhong Yiqi Wuling Decoction combined with carvedilol has a good effect in the treatment of chronic heart failure in the elderly.It can effectively improve the clinical symptoms and heart function of patients and is worthy of clinical application.
作者
郭王斌
牛静虎
曹建茹
GUO Wang-bin;NIU Jing-hu;CAO Jian-ru(Department of Geriatrics,Xi'an Hospital of Traditional Chinese Medicine,Xi'an 710021,Shaanxi,CHINA;Department of Rheumatology and Immunology,Xi'an Hospital of Traditional Chinese Medicine,Xi'an 710021,Shaanxi,CHINA;Traditional Chinese Medicine Department,Xi'an Lianhu District,Cao Qinghua Traditional Chinese Medicine Clinic,Xi'an 710003,Shaanxi,CHINA)
出处
《海南医学》
CAS
2020年第23期3029-3032,共4页
Hainan Medical Journal
关键词
慢性心力衰竭
老年
卡维地洛
补中益气五苓汤
心功能
不良反应
Chronic heart failure
Elderly
Carvedilol
Buzhong Yiqi Wuling Decoction
Heart function
Adverse reactions
