摘要
水凝胶是一种具有三维网状交联结构和良好生物相容性的亲水性材料,因其高吸水、高保水以及可模拟细胞外基质环境的特性,在伤口愈合、组织工程和药物缓释等领域得到广泛的生物医学应用。辐射技术作为水凝胶制备方式之一,具有操作简便、绿色环保、安全有效的特点,保留原材料良好的生物相容性,改性和灭菌一步完成,适合医用水凝胶的工业化生产。本文就我国辐射技术制备水凝胶及其在医用领域的应用和研究进展进行总结,并结合我国医用水凝胶的研究现状对未来的研究方向进行展望。
Hydrogels are hydrophilic,three-dimensional,polymeric networks that exhibit good biocompatibility,large water absorption ratios,strong water retention abilities,and the ability to mimic extracellular matrix structures and functions.Therefore,they are suitable for use in wound healing,tissue engineering,and drug delivery applications.Radiation techniques are simple,safe,and clean processes that have been employed to prepare high-quality hydrogels,including for mass production.Additionally,these radiation techniques retain biopolymer biocompatibility and ensure that modification and sterilization steps are completed simultaneously;this affords new opportunities for bio-applications.This paper summarizes the current research status of hydrogels in China,including their preparation by radiation technology and their biomedicine applications,and discusses prospective directions for future hydrogel research.
作者
许零
李宏伟
徐晓
XU Ling;LI Hongwei;XU Xiao(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,School of Public Health,Xiamen University,Xiamen 361102,China)
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
2020年第6期1-10,共10页
Journal of Radiation Research and Radiation Processing
关键词
水凝胶
辐射技术
医药
Radiation cross-linking
Hydrogel
Biomedicine
