摘要
目的研究依达拉奉联合丁苯肽注射液治疗急性脑梗死的临床效果。方法90例急性脑梗死患者,按随机掷骰子的方法分为观察组与对照组,每组45例。对照组单纯用依达拉奉进行治疗,观察组在对照组用药的基础上配合丁苯肽注射液进行治疗。比较两组患者治疗效果、同型半胱氨酸(Hcy)水平、C-反应蛋白(CRP)水平、美国国立卫生院神经功能缺损量表(NIHSS)评分和Barthel指数评分。结果观察组治疗总有效率为97.78%,高于对照组的77.78%,差异有统计学意义(P<0.05)。观察组治疗后Hcy为(11.52±2.33)μmol/L、CRP为(10.34±3.41)mg/L,均低于对照组的(18.34±3.78)μmol/L、(13.82±4.16)mg/L,差异有统计学意义(t=10.303、4.340,P<0.05)。观察组治疗后的NIHSS评分(7.56±1.25)分低于对照组的(12.34±2.22)分,Barthel指数评分(65.48±12.34)分高于对照组的(54.35±8.37)分,差异有统计学意义(P<0.05)。结论对急性脑梗死患者通过以依达拉奉和丁苯肽注射液联合治疗能够促进患者康复水平的提升,改善患者的功能障碍等情况,是一种优质的治疗手段。
Objective To study the clinical effect of edaravone combined with butylphthalide injection in the treatment of acute cerebral infarction.Methods A total of 90 patients with acute cerebral infarction were randomly divided into observation group and control group,with 45 cases in each group.The control group was treated with edaravone,and the observation group was treated with butylphthalide injection based on the control group.The therapeutic effect,homocysteine(Hcy)level,C-reactive protein(CRP)level,National Institutes of Health stroke scale(NIHSS)score and Barthel index score were compared between the two groups.Results The total effective rate of treatment of the observation group was 97.78%,which was higher than 77.78%of the control group,and the difference was statistically significant(P<0.05).After treatment,Hcy(11.52±2.33)μmol/L and CRP(10.34±3.41)mg/L of the observation group were lower than(18.34±3.78)μmol/L and(13.82±4.16)mg/L of the control group,and the difference was statistically significant(t=10.303,4.340,P<0.05).After treatment,NIHSS score(7.56±1.25)points of the observation group was lower than(12.34±2.22)points of the control group,and Barthel index score(65.48±12.34)points was higher than(54.35±8.37)points of the control group,and the difference was statistically significant(P<0.05).Conclusion For patients with acute cerebral infarction,edaravone combined with butylphthalide injection can promote the improvement of patients’rehabilitation level and improve their dysfunction.It is a high-quality treatment method.
作者
李铁玲
LI Tie-ling(Department of Internal Medicine-Neurology,Lingyuan Central Hospital,Lingyuan 122500,China)
出处
《中国现代药物应用》
2020年第24期105-107,共3页
Chinese Journal of Modern Drug Application
关键词
依达拉奉
急性脑梗死
丁苯肽注射液
Edaravone injection
Acute cerebral infarction
Butylphthalide injection
