摘要
目的分析比较不同剂量米非司酮治疗子宫肌瘤的临床效果。方法286例子宫肌瘤患者,按照随机数表分组法分为对照组和观察组,每组143例。两组患者均采用米非司酮治疗,对照组患者采用低剂量治疗,观察组患者采用高剂量治疗。比较两组患者临床治疗效果及治疗后肌瘤体积、雌激素[促卵泡生成激素(FSH)、雌二醇(E2)、孕酮(P)]水平。结果观察组患者临床治疗总有效率为95.1%,显著高于对照组的74.1%,差异具有统计学意义(P<0.05)。治疗后,观察组患者肌瘤体积明显小于对照组,FSH、E2、P水平均显著低于对照组,差异具有统计学意义(P<0.05)。结论米非司酮治疗子宫肌瘤具有显著效果,但高剂量的米非司酮治疗效果要明显优于低剂量,对改善患者预后具有显著的效果。
Objective To analyze and compare the clinical effect of hysteromyoma treated with different doses of mifepristone.Methods A total of 286 patients with hysteromyoma were divided into control group and observation group according to random numerical table,with 143 cases in each group.Both groups were treated with mifepristone,the control group was treated with low-dose treatment,and the observation group was treated with high-dose treatment.The clinical effect,fibroids volume,estrogen[follicle stimulating hormone(FSH),estradiol(E2),progesterone(P)]level after treatment were compared between the two groups.Results The total clinical effective rate of the observation group was 95.1%,which was significantly higher than 74.1%of the control group,and the difference was statistically significant(P<0.05).After treatment,the fibroids volume of the observation group was obviously smaller than that of the control group,and FSH,E2 and P were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Mifepristone has a significant effect in the treatment of hysteromyoma,but the therapeutic effect of high-dose mifepristone is better than that of low-dose mifepristone,which has significant effect on improving the prognosis of patients.
作者
刘继明
LIU Ji-ming(Shenfu Xincheng People’s Hospital,Fushun 113122,China)
出处
《中国现代药物应用》
2020年第24期130-132,共3页
Chinese Journal of Modern Drug Application
关键词
米非司酮
子宫肌瘤
不同剂量
Mifepristone
Hysteromyoma
Different doses
