摘要
目的观察白虎加桂枝汤加减联合汉章Ⅰ型针刀治疗急性痛风性关节炎的临床疗效。方法选取该院2016年12月至2019年10月收治的急性痛风性关节炎患者100例作为研究对象。根据治疗方法将患者分为A组、B组,每组各50例。A组给予汉章Ⅰ型针刀治疗,B组给予白虎加桂枝汤加减联合汉章Ⅰ型针刀治疗。记录2组治疗前后的疼痛程度、生活质量评分及血清细胞因子水平变化情况,并统计2组临床治疗总有效率。结果治疗后,B组总有效率为92.00%,高于A组的76.00%,差异有统计学意义(P<0.05)。治疗后,2组超敏-C反应蛋白(hs-CRP)、白细胞介素-18(IL-18)、红细胞沉降率(ESR)、白细胞计数(WBC)、高迁移率族蛋白B1(HMGB1)、环氧合酶-2(COX-2)、基质金属蛋白酶-9(MMP-9)水平及视觉模拟评分法(VAS)评分较治疗前下降,世界卫生组织生活质量测定简表(WHOQOL-BREF)评分均较治疗前上升,差异均有统计学意义(P<0.05)。治疗后,B组hs-CRP、IL-18、ESR、WBC、HMGB1、COX-2、MMP-9水平及VAS评分低于A组,WHOQOL-BREF评分高于A组,差异均有统计学意义(P<0.05)。结论白虎加桂枝汤加减联合汉章Ⅰ型针刀治疗急性痛风性关节炎可减轻炎性反应,减轻疼痛,提高疗效和生活质量。
Objective To observe the clinical efficacy of Baihu plus Guizhi decoction combined with Hanzhang typeⅠneedle knife in the treatment of acute gouty arthritis.Methods A total of 100 patients with acute gouty arthritis admitted to this hospital from December 2016 to October 2019 were selected as the research objects.According to the treatment method,the patients were divided into group A and group B,with 50 cases in each group.Group A was treated with Hanzhang typeⅠneedle knife,and group B was treated with Baihu plus Guizhi decoction combined with Hanzhang typeⅠneedle knife.The pain degree,quality of life score and serum cytokine level changes of the two groups before and after treatment were recorded,and the total effective rate of clinical treatment in the two groups were calculated.Results After treatment,the total effective rate of group B was 92.00%,which was higher than 76.00%of group A,and the difference was statistically significant(P<0.05).After treatment,the levels of hs-CRP,IL-18,ESR,WBC,HMGB1,cyclooxygenase-2,MMP-9 and VAS score in the two groups decreased compared with those before treatment,and the WHOQOL-BREF scores increased compared with those before treatment.The differences were statistically significant(P<0.05).After treatment,the levels of hs-CRP,IL-18,ESR,WBC,HMGB1,COX-2,MMP-9 and VAS score in group B were lower than those in group A,and the WHOQOL-BREF score was higher than that in group A,the differences were statistically significant(P<0.05).Conclusion Baihu plus Guizhi decoction combined with Hanzhang typeⅠneedle knife to treat acute gouty arthritis can reduce inflammatory reaction,relieve pain,improve curative effect and quality of life.
作者
刘广宇
LIU Guangyu(Department of Orthopedics,the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin,Heilongjiang 150001,China)
出处
《现代医药卫生》
2020年第24期3924-3927,共4页
Journal of Modern Medicine & Health
基金
黑龙江省中医药学会青年中医药科技创新项目(ZHY19-040)。
关键词
白虎加桂枝汤
针刀
急性痛风性关节炎
疗效
临床研究
Baihu plus Guizhi decoction
Needle knife
Acute gouty arthritis
Curative effect
Clinical research
