摘要
肺癌是全球癌症相关死亡的主要原因,每年约有160万人死于肺癌。在我国,肺癌的发病率与死亡率居首位,每年约有78万人罹患肺癌,5年生存率低于20%,且85%肺癌患者为非小细胞肺癌,70%患者发现时已是癌症晚期或肿瘤已发生转移。肺癌的治疗方法有手术切除、放疗、化疗、靶向治疗、免疫治疗,然而这些方法均具有一定局限性且毒副作用较大、价格昂贵,因此寻找价格适宜、疗效可靠的药物是当务之急。中药是我国的瑰宝,有5000余年实践经验,古籍中就有治息贲、肺积的记载,现代研究证明其具有多靶点、毒副作用小、来源广泛、效果可靠等优点,且多作为肺癌的辅助治疗方式,研究中药抗肺癌明确机制同样亟待解决。中药抗非小细胞肺癌研究主要以中药有效成分为"起点",疗效为"终点",探究"过程"——作用机制。目前,中药抗非小细胞肺癌作用机制包括诱导肿瘤细胞凋亡、自噬,抑制肿瘤细胞生长、增殖、转移、侵袭等,且已上升到分子、基因水平。该文从上述作用机制着手,以作用靶点及通路为目标,总结近年来中药抗非小细胞肺癌研究相关文献,并在前人研究基础上,对研究中所涉及中药进行了性味归经整理,以期为学者研究抗肺癌中药机制及临床应用提供思路,为肺癌与中药性味归经相关性研究提供参考。
Lung cancer is the leading cause of cancer-related deaths worldwide,and about 1.6 million people die of it each year.In China,the incidence and mortality of lung cancer rank the first,as evidenced by the fact that about 780000 people suffering from lung cancer every year,and the 5-year survival rate is less than 20%.In addition,85%of patients with lung cancer are non-small cell lung cancer(NSCLC),and 70%of lung cancer patients are found to have advanced cancer or tumor metastasis.The therapies of lung cancer include surgical resection,radiotherapy,chemotherapy,targeted therapy and immunotherapy.However,these therapies have certain limitations,severe toxic and side effects,and high costs.Therefore,it is urgent to find drugs with appropriate price and reliable efficacy.Traditional Chinese medicine(TCM)is the treasure of China,with more than 5000 years of practical experience.In ancient books,there are records of therapies for lung amassment and pneumothorax,and modern studies have proved that there are many advantages,such as multiple targets,slight side effect,wide sources and reliable effects,and it is often used as an auxiliary treatment for lung cancer.The clear mechanism of TCM against lung cancer remains to be solved.The studies on the effect of TCM against NSCLC mainly start at the effective ingredients of TCM and end at the efficacy,and explore the"process"—mechanism.At present,the mechanism of TCM against NSCLC includes inducing apoptosis and autophagy of tumor cells,inhibiting the growth,proliferation,metastasis and invasion of tumor cells,which rises to molecular and genetic level.Based on the above mechanism,aiming at the effect target and pathway,this paper summarizes the literatures of the mechanism of TCM against non-small cell lung cancer in recent years,and sorted out some anti-lung cancer TCM about property,flavor and meridian-tropism on the basis of previous studies,in order to provide ideas for scholars to study the mechanism and clinical application of TCM in resisting lung cancer,and references for the studies of the correlation between the lung cancer as well as property,flavor and meridian-tropism.
作者
程伟
陈新梅
CHENG Wei;CHEN Xin-mei(School of Pharmacy,Shandong University of Traditional Chinese Medicine,Ji′nan 250355,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第24期227-234,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
山东省中医药科技发展计划项目(2019-0022)。
关键词
非小细胞肺癌
中药
有效成分
作用机制
研究进展
non-small cell lung cancer
traditional Chinese medicine
effective constituent
mechanism
research progress
