摘要
目的探讨清肺消炎丸联合头孢丙烯分散片治疗儿童急性上呼吸道感染临床疗效。方法选取2017年1月—2019年12月在天津市滨海新区中医医院治疗的急性上呼吸道感染患儿109例,随机分为对照组(54例)和治疗组(55例)。对照组口服头孢丙烯分散片,每次7.5 mg/kg,2次/d;治疗组患儿在对照组基础上口服清肺消炎丸,2~3岁患儿20丸/次,3~6岁30丸/次,6岁~12岁40丸/次,3次/d。两组患儿疗程7~14 d。观察两组患儿临床疗效,同时比较治疗前后两组患儿症状和体征,及血清降钙素原(PCT)、白细胞介素-8(IL-8)、IL-4和半胱氨酰白三烯(CyslTs)水平。结果治疗后,治疗组总有效率是90.91%,显著高于对照组的70.37%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组体温恢复正常时间、恶心咳嗽消失时间、咽痛消失时间、鼻塞流涕时间和咽部充血消失时间都明显早于对照组(P<0.05)。治疗后,两组患儿血清PCT、1L-8、1L-4和CyslTs水平明显降低(P<0.05),且治疗组显著低于对照组(P<0.05)。结论清肺消炎丸联合头孢丙烯分散片治疗儿童急性上呼吸道感染效果突出,明显改善患儿症状和体征,降低血清炎性因子水平。
Objective To investigate the curative effect of Qingfei Xiaoyan Pills combined with cefprozil in treatment of acute upper respiratory tract infection in children.Methods Children(109 cases)with acute upper respiratory tract infection in Binhai New Area Hospital of TCM Tianjin from January 2017 to December 2019 were randomly divided into control(54 cases)and treatment(55 cases)groups.Children in the control group were po administered with Cefprozil Dispersible Tablets,7.5 mg/kg,twice daily.Children in the treatment group were po administered with Qingfei Xiaoyan Pills on the basis of the control group,20 pills/time for 2—3 years old,30 pills/time for 3—6 years old,40 pills/time for 6—12 years old,three times daily.Children in two groups were treated for 7—14 d.After treatment,the clinical efficacy was evaluated,and the symptoms and signs,the serum levels of PCT,1L-8,1L-4,and CyslTs in two groups before and after treatment were compared.Results After treatment,the total effective rate of the treatment group was 90.91%,significantly higher than that of the control group(70.37%),and there were differences between two groups(P<0.05).After treatment,the time of temperature recovering normal,the disappearance time of nausea and cough,sore throat,nasal congestion and runny nose and hyperemia of pharynx in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the serum levels of PCT,1L-8,1L-4,and CyslTs in two groups were significantly decreased(P<0.05),and which in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Qingfei Xiaoyan Pills combined with cefprozil in treatment of acute upper respiratory tract infection in children is effective,can obviously improve the symptoms and signs and reduce the inflammatory factors.
作者
宋宾
刘海
李玥
甘璐
SONG Bin;LIU Hai;LI Yue;GAN Lu(Department of Pharmacy,Binhai New Area Hospital of TCM Tianjin,Tianjin 300451,China;Department of Pediatrics,Binhai New Area Hospital of TCM Tianjin,Tianjin 300451,China)
出处
《现代药物与临床》
CAS
2020年第11期2174-2178,共5页
Drugs & Clinic
基金
天津市卫生计生委、天津市中医药管理局中医、中西医结合科研课题(2017095)。
