摘要
目的探讨子宫内膜癌和卵巢癌患者血清糖类抗原125 (CA125)和子宫动脉阻力指数(RI)治疗前后的变化情况,并分析其对患者化疗后转归的预测价值。方法选取2017年5月-2019年5月在浙江大学医学院附属杭州市第一人民医院接受治疗的女性恶性肿瘤患者60例为研究对象,包括子宫内膜癌患者33例和卵巢癌患者27例。化疗前后对两组患者进行血清CA125水平和子宫动脉RI值检测,分析两种指标的相关性,并分析其对肿瘤复发情况的预测价值。结果化疗前,两组患者血清CA125水平和子宫动脉RI值比较,差异均无统计学意义(均P>0.05)。化疗后,两组患者血清CA125水平均低于化疗前,且子宫内膜癌患者血清CA125水平明显低于卵巢癌患者,差异均有统计学意义(均P<0.05);两组患者子宫动脉RI值均高于化疗前,且子宫内膜癌患者子宫动脉RI值明显高于卵巢癌患者,差异均有统计学意义(均P<0.05)。子宫内膜癌组患者血清CA125水平与子宫动脉RI值呈负相关关系(P <0.05);而卵巢癌组患者血清CA125水平与子宫动脉RI值无明显相关性(P>0.05)。子宫内膜癌患者中,复发者化疗前及化疗后的血清CA125水平均明显高于未复发者,化疗后的子宫动脉RI值明显低于未复发者,差异均有统计学意义(均P<0.05)。卵巢癌患者中,复发者化疗后的血清CA125水平明显高于未复发者,差异有统计学意义(P<0.05)。结论监测女性恶性肿瘤患者化疗前后子宫动脉RI值和血清CA125水平的变化对于评估化疗效果、预测患者病情转归具有重要作用。建议在评估病情后尽早采取化疗,以缩减病灶并控制肿瘤新生血管的生成,进而提升肿瘤的治疗效果。
Objective To investigate the changes of serum carbohydrate antigen 125 (CA125) and uterine artery resistance index (RI) in patients with endometrial cancer and ovarian cancer before and after treatment,and to analyze their predictive value for prognosis after chemotherapy. Methods A total of 60 female patients with malignant tumor,including 33 cases of endometrial cancer and 27 cases of ovarian cancer,were selected f the Fist People’s Hospital of Hangzhou,Affiliated to School of Medicine,Zhejiang University from May 2017 to May 2019. Before and after chemotherapy,the serum CA125 level and uterine artery RI value of the two groups were detected,and the correlation between the two indicators was analyzed,and its predictive value for tumor recurrence was analyzed. Results Before chemotherapy,there was no significant difference in serum CA125 level and uterine artery RI between the two groups (P>0. 05). After chemotherapy,the serum CA125 level of the two groups was lower than that before chemotherapy,and the serum CA125 level of endometrial cancer patients was significantly lower than that of ovarian cancer patients,the differences were statistically significant (P<0. 05);the uterine artery RI value of two groups of patients were higher than that before chemotherapy,and the uterine artery RI value of endometrial cancer patients was significantly higher than that of ovarian cancer patients,the differences were statistically significant (P<0. 05). There was a negative correlation between serum CA125 level and RI value of uterine artery in endometrial cancer group (P<0. 05),but there was no significant correlation between serum CA125 level and RI value of uterine artery in ovarian cancer group (P>0. 05). In patients with endometrial cancer,the serum CA125 level of patients with recurrent endometrial cancer before and after chemotherapy was significantly higher than that of patients without recurrence,and the RI value of uterine artery after chemotherapy was significantly lower than that of patients without recurrence (P<0. 05). In patients with ovarian cancer,the serum CA125 level in patients with recurrent ovarian cancer after chemotherapy was significantly higher than that in patients without recurrence (P<0. 05). Conclusion Monitoring the changes of RI value of uterine artery and serum CA125 before and after chemotherapy plays an important role in evaluating the effect of chemotherapy and predicting the prognosis of patients. It is suggested that chemotherapy should be taken as soon as possible after the evaluation of the disease,so as to reduce the focus and control the tumor angiogenesis,so as to improve the therapeutic effect of the tumor.
作者
王雅卉
郑颖龄
杨晶
许嵩
WANG Ya-Hui;ZHENG Ying-Ling;YANG Jing(Department of Gynecology,the First People's Hospital of Hangzhou,Affiliated to School of Medicine,Zhejiang University,Hangzhou,Zhejiang 310006,China)
出处
《中国妇幼保健》
CAS
2020年第23期4416-4419,共4页
Maternal and Child Health Care of China
基金
浙江省医药卫生科技计划项目(2019KY496)。
关键词
子宫内膜癌
卵巢癌
子宫动脉
血清糖类抗原125
化疗
阻力指数
Endometrial cancer
Ovarian cancer
Uterine artery
Serum carbohydrate antigen 125
Chemotherapy
Resistance index
