摘要
目的探究血液透析对女性尿毒症患者性激素水平和月经的影响。方法回顾性分析2017年5月-2019年5月就诊于该院的80例女性尿毒症患者临床资料,将32例非血液透析治疗的患者纳入非透析组,将48例接受血液透析治疗的患者纳入透析组,并选同时期30例健康体检的女性资料为对照组。比较3组间的性激素水平以及尿毒症患者的月经情况。结果治疗前,透析组与非透析组的卵泡刺激素(FSH)、促黄体生成素(LH)、催乳素(PRL)高于对照组,孕酮(P)水平低于对照组,差异有统计学意义(P<0.05);治疗6个月后,透析组与非透析组FSH低于治疗前,LH、P、PRL高于治疗前,差异有统计学意义(P<0.05);透析组的FSH、LH、P、PRL略高于非透析组、雌二醇(E2)略低于非透析组,但差异无统计学意义(P>0.05)。透析组的月经水平正常率高于非透析组,月经紊乱率低于非透析组,差异有统计学意义(P<0.05);透析组的闭经、闭经后复潮率与非透析组比较,差异无统计学意义(P>0.05)。结论血液透析对女性尿毒症患者的性激素水平影响较小,可结合营养措施来改善患者的月经紊乱情况。
Objective To explore the effect of hemodialysis on sex hormones levels and menstruation of female patients with uremia.Methods From May 2017 to May 2019,80 female patients with uremia treated in Huzhou Hospital of Traditional Chinese Medicine were selected,the clinical data were analyzed retrospectively;80 patients were divided into non-hemodialysis group (32 patients) and hemodialysis group (48 patients). Thirty women receiving healthy physical examination during the same period were selected as control group. Sex hormones levels and menstruation conditions in the three groups were compared. Results Before treatment,the levels of follicle-stimulating hormone (FSH),luteinizing hormone (LH),and prolactin (PRL) in hemodialysis group and non-hemodialysis group were statistically significantly higher than those in control group,the level of progesterone (P) was statistically significantly lower than that in control group (P<0. 05). At 6 months after treatment,FSH levels in hemodialysis group and non-hemodialysis group were statistically significantly lower than those before treatment,LH,P,and PRL levels were statistically significantly higher than those before treatment (P<0. 05). The levels of FSH,LH,P,and PRL in hemodialysis group were slightly higher than those in non-hemodialysis group,the level of estradiol (E2) was slightly lower than that in non-hemodialysis group (P>0. 05). The normal rate of menstruation in hemodialysis group was statistically significantly higher than that in non-hemodialysis group,the incidence rate of menstrual disorder in hemodialysis group was statistically significantly lower than that in non-hemodialysis group (P<0. 05). There was no statistically significant difference in the incidence rate of amenorrhea and the recovery rate of menstruation between hemodialysis group and non-hemodialysis group (P>0. 05). Conclusion The effect of hemodialysis on sex hormones levels of female patients with uremia is small,menstrual disorder can be improved by nutritional measures.
作者
张妤
宋学权
孙梅琴
ZHANG Yu;SONG Xue-Quan;SUN Mei-Qin(Hemodialysis Room,Huzhou Hospital of Traditional Chinese Medicine,Affiliated to Zhejiang Chinese Medical University,Huzhou,Zhejiang 313000,China)
出处
《中国妇幼保健》
CAS
2020年第23期4420-4423,共4页
Maternal and Child Health Care of China
基金
浙江省中医药科技计划项目(2018ZKL045)
湖州市科学技术项目(2016GYB28)。
关键词
尿毒症
血液透析
女性
性激素
月经
Uremia
Hemodialysis
Female
Sex hormone
Menstruation
