摘要
目的探讨64层多层螺旋CT(MSCT)联合细胞增殖抗原标记物(Ki-67)和神经元特异性烯醇化酶(NSE)水平检测与周围型肺癌检出率及病理分型的关系。方法选取2017年3月至2019年3月间上海市肺科医院收治的96例周围型肺癌患者为观察组,另选取同期96例肺炎患者为对照组,比较两组患者的Ki-67、NSE水平及MSCT结果。结果观察组患者胸水、支气管征及空泡征、胸膜凹陷征、空洞征、分叶征和毛刺征发生率均高于对照组,差异均有统计学意义(均P<0.01)。观察组患者血清Ki67和NSE水平均高于对照组,差异均有统计学意义(均P<0.01)。不同TNM分期和病理分型患者的MSCT检查结果比较,差异均有统计学意义(均P<0.01)。不同TNM分期和病理分型患者的Ki67和NSE水平比较,差异均有统计学意义(均P<0.01)。多因素分析显示,MSCT、NSE和Ki67均为造成周围性肺癌患者的独立危险因素(均P<0.01)。联合检测对周围型肺癌患者的诊断效能高于单独检测,影像学指标联合Ki67和NSE水平的临界值分别为8.11ng/ml和12.36ng/ml,可作为诊断的重要依据。结论64层MSCT联合Ki-67和NSE水平检测,可提升周围型肺癌检出率,且与患者病理分型呈正相关。
Objective To study the relationship between 64 slice multi-slice computed tomography(MSCT)combined with Ki-67 and neuron-specific enolase(NSE)levels and the detection rate and pathological classification of peripheral lung cancer.Methods In this study,96 patients with peripheral lung cancer who were admitted at Shanghai Pulmonary Hospital from March 2017 to March 2019 were enrolled in an observation group and 96 patients with pneumonia were enrolled in a control group during the same period.The differences in Ki-67,NSE levels and MSCT results were compared between the two groups.Results The incidence of hydrothorax,bronchus sign,bronchus encapsulated air sign,pleural indentation,cavitary,lobulation and speculation was higher in the observation group than in the control group(all P<0.05).The level of Ki-67 and NSE were higher in the observation group than in the control group(all P<0.05).There were significant differences in MSCT test results among patients of different tumor,node and metastasis(TNM)staging and pathological classification(all P<0.05).Similarly,differences in the level of Ki-67 and NSE were significant among patients of different TNM staging and pathological classification(all P<0.05).Multivariate analysis showed MSCT,Ki-67 and NSE were risk factors causing peripheral lung cancer(all P<0.05).The efficacy of combined detection was higher than that of each single detection(all P<0.05).By analyzing the ROC curve,it discovered that the critical value was 8.11 ng/ml and 12.36 ng/ml,respectively for imaging index combined with Ki-67 and NSE levels which can be used as important evidences.Conclusion 64 slice MSCT combined with Ki-67 and NSE can significantly improve the detection rate of peripheral lung cancer,and it is positively associated with the pathological classification of patients.
作者
李岗
尤小芳
LI Gang;YOU Xiao-fang(Department of Imaging,Shanghai Pulmonary Hospital,Shanghai 200433,China)
出处
《中国肿瘤临床与康复》
2020年第11期1290-1293,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
