摘要
目的探讨腹腔镜结肠癌根治术在老年结肠癌患者中的应用效果及对炎症因子与应激反应的影响。方法选取2018年3月至2020年2月间陕西省西安市阎良区人民医院收治的98例老年结肠癌患者为研究对象。根据采用的治疗方法不同进行分组,其中,采用开腹结肠癌根治术的49例患者纳入对照组,采用腹腔镜结肠癌根治术的49例患者纳入观察组。比较两组患者术中与术后指标、血清炎症因子[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、C反应蛋白(CRP)]、氧化应激因子[丙二醛(MDA)与超氧化物歧化酶(SOD)]及术后并发症情况。结果观察组术中出血量、手术切口、肠道功能恢复时间与住院时间均低于对照组,差异均有统计学意义(均P<0.05)。术后观察组TNF-α、IL-6与CRP水平低于对照组,差异均有统计学意义(均P<0.05)。术后观察组MDA水平低于对照组,SOD水平高于对照组,差异均有统计学意义(均P<0.05)。观察组术后并发症发生率4.1%,低于对照组的16.3%,差异有统计学意义(P<0.05)。结论腹腔镜结肠癌根治术在老年结肠癌患者中具有较好的应用效果与安全性,可以有效改善机体炎症因子与应激反应,适于临床推广。
Objective To explore the effects of laparoscopic radical resection on inflammatory factors and stress response in elderly patients with colon cancer.Methods A total of 98 elderly patients with colon cancer admitted to Xi'an Yanliang District People's Hospital from March 2018 to February 2020 were selected as the study subjects.They were divided into an observation group and a control group based on the therapy they were given.Forty-nine patients undergoing laparoscopic radical resection of colon cancer were included in an observation group and 49 patients undergoing abdominal radical resection of colon cancer were included in a control group.The intraoperative and postoperative indices,serum inflammatory factors including tumor necrosis factor-α(TNF-α),interleukin(IL)-6,C-reactive protein(CRP),oxidative stress factors including malondialdehyde(MDA)and superoxide dismutase(SOD)and postoperative complications were compared between the two groups.Results The bleeding volume,incision length,recovery time of intestinal function and length of hospital stay were lower in the observation group than in the control group(all P<0.05).The levels of TNF-α,IL-6 and CRP were lower in the observation group than in the control group after the surgery(all P<0.05).The level of MDA was lower in the observation group than in the control group and the level of SOD was higher in the observation group than that in the control group(all P<0.05).The incidence of postoperative complications was 4.1%in the observation group which was lower than 16.3%of the control group(P<0.05).Conclusion Laparoscopic radical resection of colon cancer is effective and safe in elderly patients with colon cancer.It can effectively improve the inflammatory factors and stress response,and is suitable for clinical promotion.
作者
周正明
陈康
谢超
ZHOU Zheng-ming;CHEN Kang;XIE Chao(Department of General Surgery,Xi'an Yanliang District People's Hospital,Xi'an 710089,China;Department of Gastroenterology,New Campus,Huazhou District People's Hospital,Weinan 714100,China)
出处
《中国肿瘤临床与康复》
2020年第11期1325-1328,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
腹腔镜结肠癌根治术
老年
结肠肿瘤
炎症因子
应激反应
Laparoscopic radical resection of colon cancer
Elderly
Colon neoplasms
Inflammatory factors
Stress response
