摘要
[目的]优选复方夏枯草洗剂的提取工艺。[方法]采用L9(34)正交设计,以迷迭香酸、丹酚酸B的含量及出膏率的综合评分为指标,考察料液比、提取时间、提取次数对提取效果的影响,优选复方夏枯草洗剂的最佳提取工艺。[结果]根据综合评分的结果,优选出最佳提取工艺为加8倍水,提取3次,每次0.5 h。[结论]该工艺准确可靠,可行性好。
[Objective]To investigate the extraction process of Compound Xiakucao Lotion.[Methods]Orthogonal test was used to investigate effects of solid-liquid ratio,extraction time,and times on extraction process.The extraction process was optimized by comprehensive evaluation indexes based on the content of rosmarinic acid,salvianolic acid B,and the extraction yield.[Results]According to the result of comprehensive score,the optimal extraction conditions of this preparation were as follows:extracted twice with 8 times of water quantity,each for half one hour.[Conclusion]The optimized process is accurate,reliable and feasible for the industrial production of Compound Xiakucao Lotion.
作者
陆雪琴
赵亮
周洁
段彦娟
张春燕
朱建勇
翟晓翔
LU Xueqin;ZHAO Liang;ZHOU Jie;DUAN Yanjuan;ZHANG Chunyan;ZHU Jianyong;ZHAI Xiaoxiang(Department of Dermatology,Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China;Nanjing University of Chinese Medicine,Nanjing 210023,China;Central Laboratory,Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China)
出处
《天津中医药》
CAS
2020年第12期1431-1435,共5页
Tianjin Journal of Traditional Chinese Medicine
基金
2018年度浦东新区“国家中医药发展综合改革试验区”建设项目(PDZY-2018-0803)
国家自然科学基金青年基金项目(8150140723)
上海市卫生和计划生育委员会科研项目(20194Y0424)
浦东新区卫生和计划生育委员会临床中医高原学科建设项目(PDZT-2018-0604)。
关键词
复方夏枯草洗剂
正交实验
迷迭香酸
丹酚酸B
综合加权评分法
Compound Xiakucao Lotion
orthogonal experiment
rosmarinic acid
salvianolic acid B
comprehensive evaluation of multiple mark
