摘要
目的:分析经鼻蝶神经内镜垂体瘤切除术对机体应激水平、垂体功能的影响。方法:抽取安阳市人民医院2017年5月至2019年5月收治的垂体瘤患者80例,随机数字表法将患者分为两组,研究A组行经鼻蝶神经内镜垂体瘤切除术,研究B组行经颅手术治疗。比较两组肾上腺素(E)、去甲肾上腺素(NE)、肾素(R)、血管紧张素Ⅱ(ATⅡ)水平差异及促甲状腺激素(TSH)、血清游离三碘甲状腺原氨酸(FT3)、促肾上腺皮质激素(ACTH)、皮质醇(PTC)水平差异,比较两组术后并发症发生情况。结果:研究A组术后E、NE、R、ATII水平低于研究B组,差异有统计学意义(P<0.05);两组术后TSH、FT3、ACTH、PTC水平低于术前,差异有统计学意义(P<0.05);术后3个月,研究A组TSH、FT3、ACTH、PTC水平与术前比较,差异未见统计学意义(P>0.05);术后3个月,研究A组TSH、FT3、ACTH、PTC水平高于研究B组,差异有统计学意义(P<0.05);研究A组术后并发症发生率低于研究B组,差异有统计学意义(P<0.05)。结论:经鼻蝶神经内镜垂体瘤切除术治疗对患者机体应激水平、垂体功能具有一定影响,但相较于经颅手术治疗,在应激水平、垂体功能影响上较小,能够促进术后应激水平稳定与垂体功能恢复。
Objective To analyze the effect of transsphenoidal neuroendoscopic pituitary adenoma resection on stress level and pituitary function.Methods A total of 80 patients with pituitary adenoma from May 2017 to May 2019 in Anyang People’s Hospital were selected.The patients were divided into two groups by random number table.Group A underwent transsphenoidal neuroendoscopic pituitary adenoma resection and group B underwent transcranial surgery.The levels of epinephrine(E),noradrenaline(NE),renin(R),angiotensinogenⅡ(ATⅡ),thyrotropin(TSH),serum free triiodothyronine(FT3),adrenorticotropic hormone(ACTH)and plasma total Cortisol(PTC)were compared between the two groups,and the incidence of postoperative complications was compared between the two groups.Results The levels of E,NE,R and ATII in group A after operation were significantly lower than those in group B,the differences were statistically significant(P<0.05).The levels of TSH,FT3,ACTH and PTC in the two groups were significantly lower than those before operation,the differences were statistically significant(P<0.05);three months after operation,the levels of TSH,FT3,ACTH and PTC in group A were not significantly different from those before operation(P>0.05);three months after operation,the levels of TSH,FT3,ACTH and PTC in group A were significantly higher than those in group B,the differences were statistically significant(P<0.05);the incidence of postoperative complications in group A was significantly lower than that in group B,the differences were statistically significant(P<0.05).Conclusions Transsphenoidal neuroendoscopic pituitary tumor resection has a certain impact on the body stress level and pituitary function of patients,but compared with transcranial surgery,it has less influence on stress level and pituitary function,and can promote the stability of stress level and recovery of pituitary function after surgery.
作者
史霄汉
何超
王健超
Shi Xiaohan;He Chao;Wang Jianchao(Department of Neurosurgery,Anyang People’s Hospital,Anyang 455000,China;Department of Neurosurgery,Jiaxing Second Hospital,Jiaxing 314000,China)
出处
《中国实用医刊》
2020年第22期72-75,共4页
Chinese Journal of Practical Medicine
关键词
神经内镜
垂体瘤
应激水平
垂体功能
Neuroendoscope
Pituitary adenoma
Stress level
Pituitary function
