摘要
目的分析细菌性角膜炎病原学特征及危险因素。方法选取遵义医科大学附属医院收治的86例细菌性角膜炎患者为研究组,并同期选择86名健康人群为对照组。对研究组进行病原菌鉴定。比较两组甘油三酯(TG)、高密度脂蛋白(HDL-C)、总胆固醇(TC)、白细胞计数(WBC)、血红蛋白(Hb)、白蛋白(Alb)及C反应蛋白(CRP)水平。采用单因素分析及多元Logistic回归分析探讨细菌性角膜炎的危险因素。结果 86例患者中共101只病眼,分离出34株致病菌,主要致病菌为革兰阳性球菌(52.94%)和革兰阴性杆菌(38.24%)。单因素分析结果显示,两组在佩戴角膜接触镜、眼部手术史、抗菌药物使用、眼表疾病、眼部外伤或角膜异物、TC、WBC、Hb、Alb及CRP水平上比较具有统计学差异(P<0.05)。多元Logistic回归分析结果显示,佩戴角膜接触镜、眼表疾病、眼部外伤或角膜异物、血清CRP水平过高、TC及Hb水平过低是细菌性角膜炎的独立危险因素。结论细菌性角膜炎主要致病菌为革兰阳性球菌和革兰阴性杆菌。佩戴角膜接触镜、眼表疾病、眼部外伤或角膜异物以及较高的血清CRP和较低的TC及Hb水平均可导致细菌性角膜炎的发生。
OBJECTIVE To investigate the etiological characteristics and risk factors for bacterial keratitis.METHODS Totally 86 patients with bacterial keratitis who were admitted to the Affiliated Hospital of Zunyi Medical University were selected as the study group,and 86 healthy people were selected as the control group.The pathogens isolated from the study group were identified.The levels of triglyceride(TG),high density lipoprotein(HDL-C),total cholesterol(TC),white blood cell(WBC)count,hemoglobin(Hb),albumin(Alb)and C-reactive protein(CRP)were compared between the two groups.Univariate analysis and multivariate logistic regression analysis were performed for the risk factors for the bacterial keratitis.RESULTS A total of 101 diseased eyes were detected from 86 patients,and 34 strains of pathogenic bacteria were isolated,52.94%of which were gram-positive cocci,38.24%were gram-negative bacilli.Univariate analysis showed that there were significantly differences in wearing contact lens,history of eye surgery,use of antibiotic,ocular surface disease,ocular trauma or corneal foreign body,TC,WBC,Hb,Alb and CRP between the two groups(P<0.05).Multivariate logistic regression analysis showed that wearing contact lens,ocular surface disease,eye trauma or corneal foreign body,serum CRP,TC and Hb levels were the independent risk factors for bacterial keratitis.CONCLUSION The gram-positive cocci and gram-negative bacilli are dominant among the pathogens causing the bacterial keratitis.Wearing corneal contact lenses,ocular surface diseases,eye trauma or corneal foreign bodies,and levels of serum CRP,TC,and Hb can cause bacterial keratitis.
作者
李海燕
李德厚
程兴东
田凤莉
代红燕
罗鑫
LI Hai-yan;LI De-hou;CHENG Xing-dong;TIAN Feng-li;DAI Hong-yan;LUO Xin(Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou 563000,China;不详)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2020年第21期3331-3335,共5页
Chinese Journal of Nosocomiology
基金
贵州省科学技术基金资助项目[黔科合外LH字(2014)7588]。
