摘要
目的观察药灸、针刺联合腹腔灌注重组改构人肿瘤坏死因子(rmhTNF)治疗恶性腹水的临床疗效。方法将60例恶性腹水患者随机分为观察组与对照组各30例,两组均行腹腔灌注rmhTNF治疗,观察组同时接受药灸、针刺治疗,2周为1个疗程,治疗1个疗程后评价疗效。结果在腹水控制率方面,观察组总有效率为60.00%,高于对照组的33.33%(P<0.05)。在功能状态改善方面,治疗后观察组卡氏评分(KPS)评分较对照组显著提高(P<0.05)。中医临床证候改善方面,观察组总有效率为90.00%,高于对照组的66.67%(P<0.05),观察组的各项症状较对照组均有减轻,尤其腹胀、小便短少的改善显著优于对照组(P<0.05)。在临床观察期间,两组患者均未出现明显不良反应。结论药灸、针刺联合腹腔灌注rmhTNF治疗恶性腹水安全有效,能提高腹水控制率和改善患者的功能状态,显著减轻中医临床证候。
Objective:To investigate the clinical efficacy of drug moxibustion and acupuncture combined with intraperitoneal perfusion of recombinant mutant human tumor necrosis factor(rmhTNF)in the treatment of malig⁃nant ascites.Methods:Sixty patients with malignant ascites were randomly divided into the observation group and control group,30 cases in each group.The observation group received drug moxibustion and acupuncture com⁃bined with intraperitoneal perfusion of rmhTNF while the control group received intraperitoneal perfusion of rmhT⁃NF.Both groups were treated for 2 weeks as 1 course of treatment,and the efficacy was evaluated after 1 course of treatment.Results:The control rate of ascites in the observation group was 60.00%,which was higher than 33.33%of the control group with statistically significant difference(P<0.05).In the function improvement,the KPS score of the observation group after treatment was significantly higher than that of the control group,and there was a statistical difference between the two groups(P<0.05).In the improvement of clinical syndrome of TCM,the total effective rate was 90.00%in the observation group,which was significantly higher than 66.67%in the control group(P<0.05).Compared with the control group,the syndromes of the observation group were alleviated,especially the improvement of abdominal distention and urinary insufficiency(P<0.05).There were no obvious ad⁃verse reactions in both groups during clinical observation.Conclusion:It is safe and effective to treat malignant ascites with medicinal moxibustion and acupuncture combined with intraperitoneal perfusion rmhTNF,which can improve the control rate of ascites and the functional status of patients,and significantly alleviate the clinical syn⁃drome of TCM.
作者
白平
胡陵静
郭婷婷
刘楠
何苗
Bai Ping;Hu Lingjing;Guo Tingting;Liu Nan;He Miao(Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400011,China)
出处
《中国中医急症》
2020年第12期2121-2124,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
成都中医药大学杏林学者学科人才科研提升计划项目(YYZX20180035)
重庆市中医院院级名中医学术经验继承项目。
关键词
恶性腹水
药灸
针刺
RMHTNF
Malignant ascites
Drug moxibustion
Acupuncture
rmhTNF
