摘要
目的:探究胎膜早破产妇阴道分泌物B族链球菌(GBS)、肿瘤坏死因子-α(TNF-α)与新生儿不良结局。方法:选取2016年2月—2018年9月来本院诊治的胎膜早破患者55例,正常妊娠待分娩产妇50例为对照组。均采集阴道拭子标本,聚合酶链式扩增(PCR)法检测GBS,免疫比浊法检测TNF-α,分析GBS、TNF-α阳性率及新生儿分娩情况。结果:胎膜早破组GBS阳性率(27.3%)高于对照组(6.0%),TNF-α阳性率(29.1%)高于对照组(8.0%)(P<0.05)。胎膜早破组中GBS阳性、TNF-α阳性产妇新生儿肺炎、新生儿窒息、胎儿窘迫以及早产发生率均高于阴性产妇(P<0.05)。两组105例产妇中,GBS阳性、TNF-α阳性产妇新生儿肺炎、窒息,胎儿窘迫和早产的发生率均高于GBS阴性、TNF-α阴性产妇(P<0.05)。结论:GBS、TNF-α与胎膜早破有一定关系,临床应对此类孕产妇及早治疗以改善不良妊娠结局。
Objective:To explore relationship between the situation of vaginal group B streptococcus(GBS)and factor-α(TNF-α)expression of pregnant women with premature rupture of membranes and their neonatal adverse outcomes.Methods:55 pregnant women with premature rupture of membranes were selected in observation group from February 2016 to September 2018,another 50 normal pregnant women were selected in control group during the same period.The vaginal swab specimens of women in both groups were collected,and GBS was detected by polymerase chain amplification(PCR)method and TNF-αlevel was detected by immunoturbidimetry method.The positive rates of GBS and TNF-αand neonatal delivery situation in the two groups were analyzed.Results:The positive rates of GBS and TNF-αof women in the observation group were 27.3%and 29.1%,which were significant higher than those(6.0%and 8.0%)of women in the control group(P<0.05).In the observation group,the incidences of neonatal pneumonia,neonatal asphyxia,fetal distress,and preterm birth of women with GBS positive and TNF-αpositive were significant higher than those of women with GBS negative and TNF-αnegative(P<0.05).In the 105 women,the incidences of neonatal pneumonia,neonatal asphyxia,fetal distress,and preterm birth of women with GBS positive and TNF-αpositive were significant higher than those of women with GBS negative and TNF-αnegative(P<0.05).Conclusion:The GBS and TNF-αsituation of these pregnant women have certain relation with their premature rupture of membranes occurrence,so early treatment can reduce adverse pregnancy outcomes of them in clinical practice.
作者
杨帆
张建华
张瑾
杨鉴冰
杨磊
YANG Fan;ZHANG Jianhua;ZHANG Jin;YANG Jianbing;YANG Lei(The Second Affiliated Hospital of Xi 'an Medical University, Shaanxi Province, 710038;Affiliated Hospital of Shaanxi University of Chinese Medicine)
出处
《中国计划生育学杂志》
2020年第11期1887-1889,共3页
Chinese Journal of Family Planning
关键词
胎膜早破
阴道分泌物
B族链球菌
肿瘤坏死因子-Α
新生儿不良结局
Premature rupture of membranes
Vaginal secretions
Group B streptococcus
Tumor necrosis factor-α
Neonatal adverse outcomes
