摘要
目的:探究血浆置换及血小板输注治疗特发性血小板减少性紫癜疗效。方法:选择2016年2月至2019年1月于我院接受治疗的60例特发性血小板减少性紫癜患者为研究对象,按照其选择治疗方式的差异将其分为血小板输注组(20例)及血浆置换(Plasma exchange,PE)组(40例),对比两组患者治疗有效率、治疗前后血细胞计数变化情况以及治疗中各类不良反应发生情况。结果:血小板输注组患者治疗显效数10例,有效数6例,总有效率80.00%,PE组患者治疗显效数27例,有效数12例,治疗总有效率97.50%,PE组治疗总有效率高于血小板输注组(P<0.05)。与治疗前比较,PE组患者的PLT、RBC计数和Hb水平出现了明显的升高,WBC计数出现明显的下降(P<0.05),血小板输注组PLT、RBC计数和Hb水平也出现明显升高,WBC计数水平出现下降(P<0.05),但组间比较显示治疗后PE组患者上述指标均优于血小板输注组(P<0.05)。血小板输注组患者不良反应总发生人数为4人,不良反应总发生率为20.00%,PE组总不良反应发生人数3人,不良反应总发生率为7.50%,PE组不良反应总发生率明显低于血小板输注组(P<0.05)。结论:血血浆置换及血小板输注治疗均对特发性血小板减少性紫癜具有较好的治疗效果,能够显著改善患者血细胞计数异常情况,但血浆置换治疗安全性更高。
Objective:To explore the therapeutic effect of plasma exchange and platelet transfusion on idiopathic thrombocytopenic purpura.Methods:60 patients with idiopathic thrombocytopenic purpura who were treated in our hospital from February 2016 to January 2019 were selected as the research object,and they were divided into platelet transfusion group(20 cases)and plasma according to the difference in treatment options In the Plasma exchange(PE)group(40 cases),the treatment efficiency,changes in blood cell counts before and after treatment,and the occurrence of various adverse reactions during treatment were compared between the two groups.Results:In the platelet transfusion group,there were 10 cases of effective treatment,6 effective cases,and the total effective rate was 80.00%.In the PE group,there were 27 cases of effective treatment,12 effective cases,and the total effective rate was 97.50%.The difference is obvious(P<0.05).Compared with before treatment,the PLT,RBC count and Hb levels of PE patients increased significantly,the WBC count decreased significantly(P<0.05),and the PLT,RBC count and Hb levels of platelet transfusion group also increased significantly High,the WBC count level decreased(P<0.05),but the comparison between the groups showed that the above indexes of the PE group after treatment were better than the platelet transfusion group(P<0.05).The total number of adverse reactions in the platelet transfusion group was 4 and the total incidence of adverse reactions was 20.00%.The total number of adverse reactions in the PE group was 3 and the total incidence of adverse reactions was 7.50%.Lower than platelet transfusion group(P<0.05).Conclusion:Platelet transfusion and plasma exchange have a good therapeutic effect on idiopathic thrombocytopenic purpura,which can significantly improve the patient's abnormal blood cell count,but plasma exchange treatment is more safe.
作者
邓君
党娥
王文婷
田志强
尹文
DENG Jun;DANG E;WANG Wen-ting;TIAN Zhi-qiang;YIN Wen(Department of Blood Transfusion,Xijing Hospital,First Affiliated Hospital of Air Force Military Medical University,Xi'an,Shaanxi,710032,China;Department of Hematology,Xijing Hospital,First Affiliated Hospital of Air Force Military Medical University,Xi'an,Shaanxi,710032,China)
出处
《现代生物医学进展》
CAS
2020年第19期3659-3662,3608,共5页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81571914)。
