摘要
目的:探讨红花黄色素联合倍他司汀对突发性耳聋患者血液流变学、炎性因子和生活质量的影响。方法:选取2017年6月到2019年10月我院收治的123例突发性耳聋患者。根据随机数字表法分为对照组(n=61,倍他司汀治疗)和研究组(n=62,红花黄色素联合倍他司汀治疗),比较两组患者疗效、血液流变学、炎性因子和生活质量,记录两组治疗期间不良反应情况。结果:研究组治疗30 d后的临床总有效率为85.48%(53/62),高于对照组的68.85%(42/61)(P<0.05)。治疗30 d后,两组肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)水平以及纤维蛋白原、血浆黏度、血小板聚集率较治疗前下降,且研究组低于对照组(P<0.05)。两组不良反应发生率对比无差异(P>0.05)。治疗30 d后,两组白介素-10(IL-10)以及精神心理、社会活动、体能以及疼痛评分较治疗前升高,且研究组较对照组高(P<0.05)。结论:突发性耳聋患者给予倍他司汀联合红花黄色素治疗,可有效改善患者血液流变学、炎性因子和生活质量,且安全可靠,疗效确切。
Objective:To investigate the effect of safflor yellow combined with betahistine on hemorheology,inflammatory factors and quality of life in patients with sudden deafness.Methods:123 cases of sudden deafness in our hospital from June 2017 to October 2019were selected.According to the random number tablemethod,the patientswere divided into control group(n=61,betahistine)and study group(n=62,safflor yellow combined with betahistine).The curative effect,hemorheology,inflammatory factors and quality of life of the patients in the two groups were compared,and the adverse reactions of the two groups during the treatment were recorded.Results:The total clinical effective rate of the study group at 30 d after treatment was 85.48%(53/62),which was higher than 68.85%(42/61)of the control group(P<0.05).30 d after treatment,the levels of tumor necrosis factor-α(TNF-α),high sensitivity C-reactive protein(hs-CRP),fibrinogen,plasma viscosity and platelet aggregation rate of the two groups were lower than those before treatment,and those of study were lower those of control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).30 d after treatment,the scores of interleukin-10(IL-10),mental psychology,social activity,physical ability and pain score of the two groups were higher than those before treatment,and those of study group were higher than those of control group(P<0.05).Conclusion:Safflor yellow combined with betahistine is effective in the treatment of sudden deafness,which can effectively improve hemorheology,inflammatory factors and quality of life,and it is safe and reliable.
作者
伏飞达
朱晓燕
刘玉
何新亚
杨明
FU Fei-da;ZHU Xiao-yan;LIU Yu;HE Xin-ya;YANG Ming(Department of Otorhinolaryngology,Nanjing Integrated Traditional Chinese and Western Medicine Hospital,Nanjing,Jiangsu,210014,China)
出处
《现代生物医学进展》
CAS
2020年第19期3699-3702,3686,共5页
Progress in Modern Biomedicine
基金
江苏省科技计划项目(BK2014258)。
关键词
红花黄色素
倍他司汀
突发性耳聋
血液流变学
炎性因子
生活质量
Safflower yellow pigment
Betahistine
Sudden deafness
Hemorheology
Inflammatory factors
Quality of life
