摘要
布鲁氏菌病是世界范围内最常见的人兽共患传染病之一。它由胞内致病菌布鲁氏菌引起,以动物为主要宿主,人类是其第二主要宿主。布鲁氏菌能够在宿主细胞内存活和复制,通过表达不同的毒力因子和使用各种逃逸策略来逃避宿主的免疫反应,这导致了一部分布鲁氏菌病可以由急性演变到慢性从而造成疾病的迁延不愈,给患者带来严重的经济负担。基因变异的研究证实了基因多态性对人类布鲁氏菌病易感性的预期影响。由于目前布鲁氏菌病的临床表现多样,还没有批准的人类疫苗,而且治疗方法尚不确定,有复发的危险。本文重点总结了布鲁氏菌逃逸免疫系统的方法及基因多态性对疾病的可能影响,以期对未来的诊断及预防提供线索。
Brucellosis is one of the most common zoonotic infectious diseases worldwide.It is caused by the intracellular pathogen Brucella,with non-human animals as the main host,and humans as the second main host.Brucella can survive and replicate in host cells by expressing different virulence factors and using various strategies to evade the host’s immune response.Thus,brucellosis can change from acute to chronic,and the disease can continue unhealed and cause severe economic burden for patients.Studies of genetic variation have confirmed the expected effects of genetic polymorphisms on human brucellosis susceptibility.Because of the diverse clinical manifestations of brucellosis,there is no approved human vaccine,the treatment methods are uncertain,and there is a risk of recurrence.This article focuses on the mechanisms through which Brucella evades the immune system and the possible effects of genetic polymorphisms on the disease,with an aim of providing clues for future diagnosis and prevention.
作者
苏霄
赵世刚
SU Xiao;ZHAO Shi-gang(Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China;Department of Neurology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2020年第12期1029-1037,共9页
Chinese Journal of Zoonoses
基金
内蒙古自治区科技创新引导项目资助(No.KCBJ2018023)。
关键词
布鲁氏菌病
毒力因子
逃逸策略
免疫机制
基因多态性
brucellosis
virulence factors
escape strategy
immune mechanism
genetic susceptibility
