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Combined hepatocellular-cholangiocarcinoma:An update on epidemiology,classification,diagnosis and management 被引量:19

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摘要 Background:Combined hepatocellular-cholangiocarcinoma(CHC)is a rare subtype of primary hepatic malignancies,with variably reported incidence between 0.4%–14.2%of primary liver cancer cases.This study aimed to systematically review the epidemiological,clinicopathological,diagnostic and therapeutic data for this rare entity.Data sources:We reviewed the literature of diagnostic approach of CHC with special reference to its clinical,molecular and histopathological characteristics.Additional analysis of the recent literature in order to evaluate the results of surgical and systemic treatment of this entity has been accomplished.Results:The median age at CHC’s diagnosis appears to be between 50 and 75 years.Evaluation of tumor markers[alpha fetoprotein(AFP),carbohydrate antigen 19–9(CA19–9)and carcinoembryonic antigen(CEA)]along with imaging patterns provides better opportunities for CHC’s preoperative diagnosis.Reported clinicopathologic prognostic parameters possibly correlated with increased tumor recurrence and grimmer survival odds include advanced age,tumor size,nodal and distal metastases,vascular and regional organ invasion,multifocality,decreased capsule formation,stem-cell features verification and increased GGT as well as CA19–9 and CEA levels.In case of inoperable or recurrent disease,combinations of cholangiocarcinoma-directed systemic agents display superior results over sorafenib.Liver-directed methods,such as transarterial chemoembolization(TACE),percutaneous ethanol injection(PEI),hepatic arterial infusion chemotherapy(HAIC),radioembolization and ablative therapies,demonstrate inferior efficacy than in cases of hepatocellular carcinoma(HCC)due to CHC’s common hypovascularity.Conclusions:CHC demonstrates an overlapping clinical and biological pattern between its malignant ingredients.Natural history of the disease seems to be determined by the predominant tumor element.Gold standard for diagnosis is histology of surgical specimens.Regarding therapeutic interventions,major hepatectomy is acknowledged as the cornerstone of treatment whereas minor hepatectomy and liver transplantation may be applied in patients with advanced cirrhosis.Despite all therapeutic attempts,prognosis of CHC remains dismal.
出处 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2020年第6期515-523,共9页 国际肝胆胰疾病杂志(英文版)
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  • 1Xian-Huan Yu,Lei-Bo Xu,Hong Zeng,Rui Zhang,Jie Wang and Chao LiuAuthor Affiliations:Department of Hepato-Pancreato-Biliary Surgery and Department of Pathology,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510120,China.Clinicopathological analysis of 14 patients with combined hepatocellular carcinoma and cholangiocarcinoma[J].Hepatobiliary & Pancreatic Diseases International,2011,10(6):620-625. 被引量:7
  • 2Gao, Chun,Yao, Shu-Kun.Diabetes mellitus: a “true” independent risk factor for hepatocellular carcinoma?[J].Hepatobiliary & Pancreatic Diseases International,2009,8(5):465-473. 被引量:23
  • 3Zuo, Huai-Quan,Yan, Lu-Nan,Zeng, Yong,Yang, Jia-Ying,Luo, Hong-Zhi,Liu, Jiang-Wen,Zhou, Li-Xin.Clinicopathological characteristics of 15 patients with combined hepatocellular carcinoma and cholangiocarcinoma[J].Hepatobiliary & Pancreatic Diseases International,2007,6(2):161-165. 被引量:13
  • 4Xue-Shuai Wan,Yi-Yao Xu,Jun-Yan Qian,Xiao-Bo Yang,An-Qiang Wang,Lian He,Hai-Tao Zhao,Xin-Ting Sang.Intraductal papillary neoplasm of the bile duct[J].World Journal of Gastroenterology,2013,19(46):8595-8604. 被引量:20
  • 5The general rules for the clinical and pathological study of primary liver cancer[J]. The Japanese Journal of Surgery . 1989 (1)
  • 6William C. Palmer,Tushar Patel.Are common factors involved in the pathogenesis of primary liver cancers? A meta-analysis of risk factors for intrahepatic cholangiocarcinoma[J].Journal of Hepatology.2012(1)
  • 7Zongtang Sun,Taoyang Chen,Snorri S. Thorgeirsson,Qimin Zhan,Jianguo Chen,Ju-Hyun Park,Peixin Lu,Chu Chieh Hsia,Nengjin Wang,Libin Xu,Lingling Lu,Fei Huang,Yuanrong Zhu,Jianhua Lu,Zhengping Ni,Qinan Zhang,Yuying Wu,Guoting Liu,Zhiyuan Wu,Chunfeng Qu,Mitchell H. Gail.Dramatic reduction of liver cancer incidence in young adults: 28 year follow-up of etiological interventions in an endemic area of China[J].Carcinogenesis.2013(8)
  • 8Jun Akiba,Osamu Nakashima,Satoshi Hattori,Ken Tanikawa,Miki Takenaka,Masamich Nakayama,Reiichiro Kondo,Yoriko Nomura,Keiko Koura,Kousuke Ueda,Sakiko Sanada,Yoshiki Naito,Rin Yamaguchi,Hirohisa Yano.Clinicopathologic Analysis of Combined Hepatocellular-Cholangiocarcinoma According to the Latest WHO Classification[J].The American Journal of Surgical Pathology.2013(4)
  • 9Chern‐Horng Lee,Sen‐Yung Hsieh,Chee‐Jen Chang,Yu‐Jr Lin.Comparison of clinical characteristics of combined hepatocellular‐cholangiocarcinoma and other primary liver cancers[J].J Gastroenterol Hepatol.2012(1)
  • 10Jiayi Huang,Lihong Shen,Yongliang Lu,Hongli Li,Xifeng Zhang,Daixi Hu,Tao Feng,Fangzhou Song.Parallel induction of cell proliferation and inhibition of cell differentiationin hepatic progenitor cells by hepatitis B virus X gene[J].International Journal of Molecular Medicine.2012(4)

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