摘要
目的观察止痛通痹液治疗腰椎间盘突出症的临床效果及对患者血清炎症指标和PGE2水平的影响。方法选取2017年6月~2020年6月在我院接受治疗的60例腰椎间盘突出症患者为研究对象,采用随机数字表法分为对照组和观察组,各30例。对照组采用常规治疗,观察组在对照组基础上加用止痛通痹液治疗,比较两组临床治疗效果、VAS评分、JOA评分、ODI评分、血清炎症指标、PGE2水平及不良反应发生情况。结果观察组治疗总有效率为96.67%,高于对照组的83.33%,差异有统计学意义(P<0.05);治疗后两组VAS评分、ODI评分均低于治疗前,JOA评分高于治疗前,且观察组VAS评分、ODI评分均低于对照组,JOA评分高于对照组,差异有统计学意义(P<0.05);治疗后两组TNF-α、IL-1β、IL-6、PGE2水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论止痛通痹液治疗腰椎间盘突出症效果确切,可提高治疗效果,有效改善患者疼痛,提高腰椎功能,促进腰椎恢复,降低炎症因子和PGE2水平,不良反应少,安全性良好,值得临床应用。
Objective To observe the clinical effect of Zhitongtongbi Liquid in treating prolapse of lumbar intervertebral disc and its influence on patients'serum inflammatory indexes and PGE2 levels.Methods A total of 60 patients with prolapse of lumbar intervertebral disc who were treated in our hospital from June 2017 to June 2020 were selected as the research objects.They were divided into the control group and the observation group by random number table method,with 30 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with Zhitongtongbi Liquid on the basis of the control group.The clinical treatment effect,VAS score,JOA score,ODI score,serum inflammation index,PGE2 level and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.67%,which was higher than 83.33% in the control group,the difference was statistically significant(P<0.05);after treatment,the VAS score and ODI score of the two groups were lower than before treatment,and the JOA score was higher than before treatment,the VAS score and ODI score of the observation group were lower than those of the control group,and the JOA score was higher than that of the control group,the difference was statistically significant(P<0.05);after treatment,the two groups of TNF-α,IL-1β,IL-6,PGE2 The level was lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);the difference in the incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion Zhitongtongbi Liquid is effective in treating prolapse of lumbar intervertebral disc.It can improve the treatment effect,effectively improve the patient's pain,improve the lumbar function,promote the recovery of the lumbar spine,reduce the level of inflammatory factors and PGE2,with few adverse reactions,good safety,and it is worthy of clinical application.
作者
戴志鹏
DAI Zhi-peng(Department of Pharmacy,Jinxi County People's Hospital,Jinxi 344800,Jiangxi,China)
出处
《医学信息》
2020年第24期154-156,共3页
Journal of Medical Information
关键词
止痛通痹液
腰椎间盘突出症
炎症因子
PGE2
Zhitongtongbi liquid
Prolapse of lumbar intervertebral disc
Inflammatory factor
PGE2
