摘要
目的探讨中性粒细胞/淋巴细胞比值(NLR)、血清CA125及CA199检测在子宫腺肌病和子宫内膜异位症中的临床意义。方法选取2018年2月~2019年10月江西省妇幼保健院收治的52例子宫内膜异位症患者、50例子宫腺肌病患者分别作为观察1组、观察2组,同时选取50名健康育龄女性作为对照组,三组均进行NLR、血清CA125及CA199检测,比较三组的NLR、血清CA125及CA199水平、三组NLR、血清CA125及CA199单独及联合检测的阳性率。结果观察1、2组患者的NLR、血清CA125及CA199水平高于对照组,差异有统计学意义(P<0.05)。观察2组患者的血清CA125水平高于观察1组,CA199水平低于观察1组,差异有统计学意义(P<0.05)。观察1组患者不同分期的NLR、血清CA125及CA199水平比较,差异有统计学意义(P<0.05)。观察1、2组患者的NLR、血清CA125及CA199单独及联合检测的阳性率均高于对照组,差异有统计学意义(P<0.05)。观察1、2组患者的联合检测阳性率均高于单一指标检测,差异有统计学意义(P<0.05)。观察1组血清CA199检测阳性率高于观察2组,差异有统计学意义(P<0.05)。结论NLR、血清CA125及CA199联合检测用于子宫内膜异位症和子宫腺肌病检出具有显著应用价值,可明确子宫内膜异位症的病理分期,值得临床推广应用。
Objective To investigate the clinical significance of neutrophil/lymphocyte ratio(NLR),serum CA125 and CA199 detection in adenomyosis and endometriosis.Methods A total of 52 patients with endometriosis and 50 patients with adenomyosis who admitted to Jiangxi Maternal and Child Health Hospital from February 2018 to October 2019 were selected as observation group 1 and 2,and 50 healthy women of childbearing age were selected as control group.NLR,serum CA125 and CA199 were detected in all three groups,and the levels of NLR,serum CA125 and CA199,positive rates of NLR,serum CA125,CA199 and combined detection among the three groups were compared.Results The levels of NLR,serum CA125 and CA199 in observation group 1 and 2 were higher than those in control group,and the differences were statistically significant(P<0.05).The level of serum CA125 in observation group 2 was higher than that in observation group 1,the level of CA199 was lower than that in observation group 1,and the differences were statistically significant(P<0.05).There were statistically significant differences in levels of NLR,serum CA125 and CA199 in different stages in the observation group 1(P<0.05).The positive rates of NLR,serum CA125,CA199 and combined detection in observation group 1 and 2 were higher than those in control group,and the differences were statistically significant(P<0.05).The positive rate of combined detection in observation group 1 and 2 were higher than those in the single index detection,and the differences were statistically significant(P<0.05).The positive rate of serum CA199 detection in observation group 1 was higher than that in observation group 2,and the difference was statistically significant(P<0.05).Conclusion The combined detection of NLR,serum CA125 and CA199 in the detection of endometriosis and adenomyosis has significant application value,it can identify the pathological stages of endometriosis,and it is worthy of clinical promotion and application.
作者
苏家林
张赟
卢朝霞
吴海根
SU Jia-lin;ZHANG Yun;LU Chao-xia;WU Hai-gen(Department of Gynecology and Obstetrics,Jiangxi Maternal and Child Health Hospital,Jiangxi Province,Nanchang 330000,China)
出处
《中国当代医药》
2021年第1期132-134,138,共4页
China Modern Medicine
基金
江西省卫生厅科技计划项目(20141140)。
