摘要
目的:探讨多潘立酮联合铝碳酸镁在胆汁反流性胃炎患者中的应用效果。方法:选择2018年3月-2020年3月收治的83例胆汁反流性胃炎患者,按照不同的治疗方案分为对照组(多潘立酮治疗,42例)与观察组(多潘立酮联合铝碳酸镁治疗,41例),对比两组患者的治疗效果。结果:观察组治疗有效率(95.1%)明显高于对照组(81.0%),差异有统计学意义(P<0.05);治疗后,观察组胃液胆酸含量及胃酸分泌量少于对照组(P<0.05);治疗24 h后,观察组各项胆汁反流检测结果(胆汁反流总时间占比、反流次数、最长反流时间、反流持续时间超过5 min的次数)均明显优于对照组(P<0.05);观察组各项症状改善时间(胆汁反流消失时间、黏膜充血消失时间、黏膜水肿消失时间)均明显短于对照组(P<0.05);观察组患者胆汁pH值>4所占的时间百分比明显高于对照组(P<0.05);两组不良反应发生率对比差异无统计学意义(P>0.05)。结论:多潘立酮联合铝碳酸镁在胆汁反流性胃炎患者的临床治疗中具有显著的应用效果,具有较高的有效性及安全性。
Objective:To explore the effect of Domperidone combined with Aluminum Magnesium Carbonate in patients with bile reflux gastritis.Method:Eighty-three patients with bile reflux gastritis admitted from March 2018 to March 2020 were divided into the control group(Domperidone treatment,42 cases)and the observation group(Domperidone combined with Aluminum Magnesium Carbonate treatment,41 cases).Result:The treatment effective rate(95.1%)of the observation group was significantly higher than that of the control group(81.0%),and the difference was statistically significant(P<0.05);after treatment,the gastric juice bile acid content and gastric acid secretion of the observation group were lower than those of the control group(P<0.05);after 24 hours of treatment,the test results of bile reflux in the observation group(the proportion of total bile reflux time,the number of reflux times,the longest reflux time,and the number of times the reflux duration exceeded 5 min)were significantly better than those in the control group(P<0.05);the time to improve the symptoms(the disappearance time of bile reflux,the disappearance time of mucosal hyperemia,and the disappearance time of mucosal edema)of the observation group were significantly shorter than those of the control group(P<0.05);the time ratio of pH>4 of the observation group was significantly higher than that of the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Domperidone combined with Aluminum Magnesium Carbonate has a significant application effect in the clinical treatment of patients with bile reflux gastritis,,and has high effectiveness and safety.
作者
周雪
ZHOU Xue(Chongqing Changshou District People’s Hospital,Chongqing 400012,China)
出处
《中外医学研究》
2020年第34期149-151,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
胆汁反流性胃炎
多潘立酮
铝碳酸镁
Bile reflux gastritis
Domperidone
Aluminum Magnesium Carbonate
