摘要
目的:对沙美特罗替卡松粉吸入剂、肺力咳合剂联合酮替芬在小儿哮喘疾病治疗中的效果加以研究,并观察其对患儿IgE、T淋巴细胞亚群、IL-4等的影响。方法:按随机双盲法,将笔者所在医院于2019年4月-2020年3月所收治的88例哮喘患儿分成两组,即基础组(n=44)与联合组(n=44),对前者予以酮替芬治疗,对后者予以沙美特罗替卡松粉吸入剂+肺力咳合剂+酮替芬治疗。比较两组患儿的临床效果及IgE、IL-4、T淋巴细胞亚群等指标情况。结果:联合组患儿治疗后总有效率为93.2%,高于基础组的77.3%,差异有统计学意义(χ^2=4.423,P<0.05);联合组患儿治疗后的IgE、IL-4及T淋巴细胞亚群(CD3^+、CD4^+、CD8^+)等指标均优于本组治疗前及基础组治疗后,差异均有统计学意义(P<0.05)。结论:对哮喘患儿予以沙美特罗替卡松粉吸入剂、肺力咳合剂及酮替芬联合治疗,效果明显,且能改善患儿的炎症及T淋巴细胞亚群,值得大力推广。
Objective:To study the effect of Salmeterol Fluticasone Powder Inhalation,Feilike Mixture combined with Ketotifen in the treatment of children with asthma,and to observe the effect on IgE,T lymphocyte subsets and IL-4 in children.Method:According to the random double-blind method,88 children with asthma admitted to our hospital from April 2019 to March 2020 were divided into two groups,namely the basic group(n=44)and the combined group(n=44).The former was treated with Ketotifen,and the latter was treated with Salmeterol Fluticasone Powder Inhalation+Feilike Mixture+Ketotifen.The clinical effects and the IgE,IL-4,T lymphocyte subsets indicators were compared between the two groups.Result:After treatment,the total effective rate of the combined group(93.2%)was higher than that of the basic group(77.3%),the difference was statistically significant(χ^2=4.423,P<0.05);the IgE,IL-4 and T lymphocyte subsets(CD3^+,CD4^+,CD8^+)and other indicators in the combined group were better than those before treatment and after treatment in the basic group,the differences were statistically significant(P<0.05).Conclusion:Salmeterol Fluticasone Powder Inhalation,Feilike Mixture and Ketotifen combined treatment has obvious effect,and can improve the children’s inflammation and T lymphocyte subsets,which is worthy of promotion.
作者
周有峰
王世彪
ZHOU Youfeng;WANG Shibiao(Fujian Maternal and Child Health Hospital,Fuzhou 350001,China;不详)
出处
《中外医学研究》
2020年第34期154-155,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
小儿哮喘
沙美特罗替卡松粉吸入剂
肺力咳合剂
酮替芬
Children with asthma
Salmeterol Fluticasone Powder Inhaler
Feilike Mixture
Ketotifen
