摘要
目的探讨团体艺术治疗联合盐酸文拉法辛对伴有躯体症状的围绝经期首发抑郁障碍的疗效及影响因素。方法将符合ICD-10中度抑郁发作(伴躯体症状)诊断标准的120例围绝经期首发抑郁障碍女性患者,依据随机数字表法分为试验组和对照组,试验组给予团体艺术治疗联合盐酸文拉法辛治疗,对照组单用盐酸文拉法辛治疗,疗程4周。治疗基线、2周末、4周末分别对两组患者HAMD-17评分、HAMD-17减分率、Kupperman评分、SCL-90躯体化因子分进行评定。采用SPSS 19.0软件对数据进行分析,分别采用χ2检验和配对t检验。结果试验组总有效率为86.67%,对照组总有效率71.67%,两组相比差异有统计学意义(χ2=4.093,P=0.043);两组治疗后HAMD-17评分、SCL-90躯体化因子分、Kupperman评分均较治疗前下降,治疗第4周末,试验组HAMD-17评分显著低于对照组,两组差异有统计学意义(t=6.251,P=0.006),Kupperman评分和SCL-90躯体化因子分两组差异均有统计学意义(t=4.116,P=0.025;t=8.034,P=0.001)。结论团体艺术治疗联合盐酸文拉法辛对围绝经期首发抑郁障碍的躯体症状疗效较好。
Objective To investigate the effect of group art therapy combined with venlafaxine for perimenopausal depression with somatic symptoms.Methods One hundred and twenty female patients with moderate depressive episode(with somatic symptoms)who met the diagnostic criteria of ICD-10 were divided into the study group and the control group according to the random number table.The study group was given group art therapy combined with venlafaxine therapy,while the control group was given venlafaxine therapy alone for 4 weeks.HAMD-17 score,HAMD-17 reduction rate,Kupperman score and SCL-90 somatization factor score of the two groups were evaluated before treatment,2 weeks and 4 weeks after treatment.SPSS 19.0 software was used to analyze the data,and chi-square test and paired t-test were used respectively.Results The total effective rate was 86.67%in the study group and 71.67%in the control group(χ2=4.093,P=0.043).HAMD-17 score,SCL-90 somatization factor score and Kupperman score in both groups decreased after treatment.At the end of the fourth week of treatment,HAMD-17 score in the study group was significantly lower than that in the control group(t=6.251,P=0.006).The differences of Kupperman score and SCL-90 somatization factor were statistically significant(t=4.116,P=0.025;t=8.034,P=0.001).Conclusion Group art therapy combined with venlafaxine has a better efficacy for perimenopausal depressive disorder with somatic symptoms.
作者
傅燚
陈诗恩
崔海松
张琼
吴佳馨
陆峥
FU Yi;CHEN Shi-en;CUI Hai-song;ZHANG Qiong;WU Jia-xin;LU Zheng(Dept.of Psychiatry,Tongji Hospital,Tongji University School of Medicine,Shanghai 200065,China)
出处
《同济大学学报（医学版）》
CAS
2020年第6期717-721,共5页
Journal of Tongji University(Medical Science)
基金
上海市临床重点专科建设项目(2018)
上海市重中之重临床重点学科建设计划(2017ZZ02020)
上海市心身医学重要薄弱学科建设项目(2019ZB0202)
