摘要
目的探讨三维适形放疗对直肠癌术后患者血清癌胚抗原(CEA)、瘦素、血管内皮生长因子(VEGF)水平的影响。方法 94例直肠癌患者均接受手术治疗,依据术后治疗方法分为对照组和研究组,每组47例,对照组患者接受常规放疗,研究组患者接受三维适形放疗。治疗前后,比较两组患者血清CEA、瘦素、VEGF水平;随访1、2、3年,比较两组患者的生存情况和复发情况;比较两组患者治疗过程中的不良反应发生情况,包括放射性直肠炎和放射性膀胱炎。结果治疗前,两组患者血清CEA、瘦素、VEGF水平比较,差异均无统计学意义(P> 0.05)。治疗后,研究组患者血清CEA、VEGF水平均低于对照组,瘦素水平高于对照组患者,差异均有统计学意义(P<0.05)。术后1、2、3年,研究组患者的局部复发率均低于对照组患者,无病生存率均高于对照组患者,差异均有统计学意义(P<0.05)。术后1、2年,两组患者的总生存率比较,差异均无统计学意义(P> 0.05);术后3年,研究组患者的总生存率高于对照组患者,差异有统计学意义(P <0.05)。研究组患者放射性膀胱炎和放射性直肠炎发生率均低于对照组患者,差异均有统计学意义(P<0.05)。结论三维适形放疗可降低直肠癌患者血清CEA、VEGF水平,提高血清瘦素水平,还可降低复发风险,提高生存率。
Objective To investigate the effect of postoperative 3 D conformal radiotherapy on serum carcinoembryonic antigen(CEA),leptin and vascular endothelial growth factor(VEGF)levels in patients with rectal cancer.Method 94 surgical treated patients with rectal cancer were randomly divided into the control group(n=47,treated with conventional radiotherapy)and study group(n=47,treated with 3 D conformal radiotherapy).The serum CEA,leptin and VEGF levels of the two groups before and after treatment were compared;the 1-,2-and 3-year survival and recurrence of the two groups were compared;the adverse reactions including radioactive rectitis and radioactive cystitis during treatment were compared.Result There were no significant differences in serum CEA,leptin and VEGF levels between the two groups before treatment(P>0.05).After treatment,the serum CEA and VEGF levels of the study group were lower than those of the control group,and the leptin level was higher than that of the control group,the differences were statistically significant(P<0.05).The 1-,2-and 3-year postoperative local recurrence rate and disease-free survival rate of the study group were lower than those in the control group(P<0.05).There was no significant difference for 1-and 2-year postoperative overall survival rate between the two groups(P>0.05);the 3-year postoperative overall survival rate in the study group was lower than that in the control group(P<0.05).The incidence of radioactive cystitis and radioactive rectitis in the study group was lower than that in the control group(P<0.05).Conclusion 3 D conformal radiotherapy can reduce the serum CEA,VEGF levels,increase the leptin levels,decrease the recurrence rate and improve the survival rate in rectal cancer patients.
作者
张晶
何学军
路逵
包赟
陈珏
ZHANG Jing;HE Xuejun;LU Kui;BAO Yun;CHEN Yu(Department of Oncology,Taizhou Second People’s Hospital,Taizhou 225599,Jiangsu,China)
出处
《癌症进展》
2020年第23期2442-2445,共4页
Oncology Progress
