摘要
目的分析复发性阿弗他溃疡(recurrent aphthous ulcer,RAU)患者血清锌水平、T淋巴细胞亚群之间的关系。方法收集2016年1月~2020年2月在笔者医院口腔科诊断为RAU的患者115例作为观察组,同期选择60例无口腔溃疡就诊患者作为对照组,采用比色法检测锌水平,流式细胞术检测CD3^+、CD4^+、CD8^+细胞数量及CD4^+/CD8^+比值。采用t检验比较两组指标之间的差异;方差膨胀因子诊断法排除具有共线性的指标,Logistic回归模型分析各指标在RAU患者中的危险程度。结果RAU组与对照组血清锌、CD3^+、CD4^+、CD8^+水平比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,年龄、血清锌、CD4^+为RAU发病的独立危险因素(P<0.05)。结论RAU患者中血清锌减少、T淋巴细胞亚群水平下降;二者之间相关性有待于进一步明确。
Objective To analyze the relationship between serum zinc levels and T lymphocyte subsets in patients with recurrent aphthous ulcer(RAU).Methods From January 2016 to February 2020,115 patients diagnosed with RAU in our department of stomatology were selected as the observation group,and 60 patients without oral ulcers were selected as the control group.Colorimetric method was used to detect zinc level.Flow cytometry was used to detect the number of CD3^+,CD4^+,CD8^+cells and the ratio of CD4^+/CD8^+.The t test was used to compare the differences between the two groups of indicators,the variance inflation factor to exclude indicators with collinearity,and the Logistic regression model was used to analyze the risk of each indicator in RAU patients.Results Compared with the control group,the levels of serum zinc,CD3^+,CD4^+,and CD8^+in the RAU group were statistically different(P<0.05).Multivariate Logistic regression analysis showed that age,serum zinc,and CD4^+were independent risk factors for the incidence of RAU(P<0.05).Conclusion Serum zinc is reduced and T lymphocyte subset levels are reduced in RAU patients.The correlation between the two needs to be further studied.
作者
陈晓涛
王紫莹
库尔班·吾甫尔
张淼
Chen Xiaotao;Wang Ziying;Kuerban·Wufuer(Department of Stomatology,The People′s Hospital of the Xinjiang Uygur Autonomous Region,Xinjiang 830001,China)
出处
《医学研究杂志》
2020年第12期33-35,40,共4页
Journal of Medical Research
基金
国家自然科学基金资助项目(81660185)。
