摘要
目的:研究依帕司他对2型糖尿病周围神经病变(DPN)患者血清神经调节蛋白4(Nrg4)及胱抑素C(Cys C)的影响。方法:将2018年6月-2019年6月于笔者所在医院内分泌科门诊及住院部就诊的66例新诊断伴有DPN的T2DM患者(DPN)随机分为对照组(n=33),观察组(n=33)。对照组、观察组分别给予二甲双胍治疗、二甲双胍+依帕司他治疗。对比两组患者治疗前后血清Nrg4、Cys C水平及振动感知阈值(VPT)。结果:两组患者的基础血清Nrg4、Cys C水平及VPT差异无统计学意义(P>0.05)。治疗后,观察组患者的血清Nrg4较对照组明显增加(P<0.05),而Cys C水平及VPT较对照组明显下降(P<0.05)。结论:依帕司他可以改善2型DPN患者的血清Nrg4、Cys C水平以及VPT,提示其对2型DPN有较好的治疗价值。
Objective:To study the effect of Epalrestat on serum neuromodulatory protein 4(Nrg4)and cystatin C(Cys C)in patients with type 2 diabetic peripheral neuropathy(DPN).Method:From June 2018 to June 2019,66 newly diagnosed T2DM patients with DPN were randomly divided into control group(n=33)and observation group(n=33).The control group was treated with Metformin,and the observation group was treated with Metformin and Epalrestat.The levels of serum Nrg4,Cys C and vibration perception threshold(VPT)were compared between the two groups before and after treatment.Result:There was no significant difference in the basic serum Nrg4,Cys C levels and VPT between the two groups(P>0.05).After treatment,the serum Nrg4 in the observation group was significantly higher than that in the control group(P<0.05),while the Cys C level and VPT in the observation group were significantly lower than those in the control group(P<0.05).Conclusion:Epalrestat can improve the levels of nrg4,Cys C and VPT in patients with type 2 DPN,suggested that Epalrestat has better therapeutic value for type 2 DPN.
作者
王柳雯
WANG Liuwen(Liuzhou People’s Hospital,Liuzhou 545006,China)
出处
《中外医学研究》
2020年第36期22-24,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
广西壮族自治区卫生厅科研课题项目(Z20170706)。
