摘要
目的:探讨联用雷贝拉唑和替普瑞酮治疗慢性胃炎的临床效果及对复发率的影响。方法:选取2018年3月-2020年2月来笔者所在医院就诊的慢性胃炎患者108例,随机分成两组,每组54例,对照组采用雷贝拉唑治疗,观察组联用雷贝拉唑和替普瑞酮治疗,观察分析两组患者临床疗效、临床症状消失时间、治疗前后胃黏膜修复状况、不良反应发生状况及复发率的差异。结果:观察组患者临床疗效为88.89%,明显高于对照组的74.07%(P<0.05)。观察组患者上腹痛、腹胀、反酸消失时间均短于对照组(P<0.05)。观察组患者胃黏膜修复状况较对照组患者更优(P<0.05)。治疗期间,两组患者均未发生血尿常规异常、严重肝肾异常等不良反应。随访发现,观察组患者复发率为6.25%,显著低于对照组的22.50%(P<0.05)。结论:联用雷贝拉唑和替普瑞酮治疗慢性胃炎,临床疗效更好,可促进患者临床症状的早期缓解,促进胃黏膜修复,且不易复发,安全性较高,值得临床推广。
Objective:To investigate the clinical efficacy of Rabeprazole and Teprenone in the treatment of chronic gastritis and its influence on recurrence rate.Method:From March 2018 to February 2020 in our hospital 108 cases of patients with chronic gastritis,randomly divided into two groups,each group of 54 cases,control group adopted Rabeprazole treatment,observation group adopted Rabeprazole combined with Teprenone treatment,to observe the clinical efficacy analysis of two groups of patients,the clinical symptoms disappear time,gastric mucosa repair status before and after the treatment,the recurrence rate,and adverse reactions occur.Result:The clinical efficacy of the observation group was 88.89%,significantly higher than 74.07%of the control group(P<0.05).The disappearance time of symptoms of upper abdominal pain,abdominal distension and acid reflux in the observation group was shorter than those in the control group(P<0.05).The gastric mucosa repair in the observation group was better than that in the control group(P<0.05).During the treatment,no abnormal hematuria routine,severe liver and kidney abnormalities or other adverse reactions occurred in the two groups.After follow-up,the recurrence rate in the observation group was 6.25%,significantly lower than 22.50%in the control group(P<0.05).Conclusion:The combination of Rabeprazole and Teprenone in the treatment of chronic gastritis has a better clinical effect,can promote the early remission of clinical symptoms,promote the repair of gastric mucosa,and is not easy to relapse,high safety,and is worthy of clinical promotion.
作者
罗德林
蒋义贵
LUO Delin;JIANG Yigui(General Hospital of Jianning County,Jianning 354500,China;不详)
出处
《中外医学研究》
2020年第36期138-140,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
雷贝拉唑
替普瑞酮
慢性胃炎
临床疗效
复发率
不良反应
Rabeprazole
Teprexone
Chronic gastritis
Clinical efficacy
Recurrence rate
Adverse reactions
