摘要
目的:观察平心复脉合剂联合琥珀酸美托洛尔缓释片对频发室性早搏的疗效及对心率变异性的影响。方法:纳入气阴两虚型频发室性早搏患者80例,采用随机数字表法分为治疗组和对照组各40例。对照组予琥珀酸美托洛尔缓释片治疗,治疗组在对照组基础上加用平心复脉合剂,共治疗4周。比较2组治疗前后心率变异性指标、临床疗效及不良反应发生率。结果:总有效率治疗组为90.0%,对照组为72.5%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组心率变异性指标比较,差异均无统计学意义(P>0.05)。治疗后,2组间期标准差(SDNN)、连续正常间距差的均方根(rMSSD)、高频功率(HF)均较治疗前增大(P<0.05),低频功率(LF)较治疗前减小(P<0.05);治疗组SDNN、rMSSD、HF均大于对照组,LF小于对照组(P<0.05)。2组不良反应发生率均为2.50%,组间比较,差异无统计学意义(P>0.05)。结论:平心复脉合剂联合琥珀酸美托洛尔缓释片治疗频发室性早搏,能改善患者心率变异性,安全有效。
Objective:To observe the curative effect of Pingxin Fumai mixture combined with metoprolol succinate sustained-release tablets on frequent premature ventricular contractions and its effect on the heart rate variability.Methods:A total of 80 cases of patients with frequent premature ventricular contractions of qi-yin deficiency type were enrolled and divided into the treatment group and the control group according to the random number table method,40 cases in each group.The control group was given metoprolol succinate sustained-release tablets,and the treatment group was additionally given Pingxin Fumai mixture based on the treatment of the control group.Both groups were treated for four weeks.The indexes of the heart rate variability before and after treatment,clinical effect,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate was 90.0%in the treatment group,and 72.5%in the control group,the difference being significant(P<0.05).Before treatment,there was no significance in the difference being found in the comparison of indexes of the heart rate variability between the two groups(P>0.05).After treatment,the standard deviation of normal-to-normal intervals(SDNN),root mean square of successive differences of normal-to-normal intervals(rMSSD),and high frequency(HF)in the two groups were increased when compared with those before treatment(P<0.05),and low frequency(LF)was decreased when compared with that before treatment(P<0.05).After treatment,SDNN,rMSSD and HF in the treatment group were larger than those in the control group,and LF was smaller than that in the control group(P<0.05).The incidence of adverse reactions was 2.50%in the two groups,there being no significance in the difference between the two groups(P>0.05).Conclusion:In the treatment of frequent premature ventricular contractions,the therapy of Pingxin Fumai mixture combined with metoprolol succinate sustained-release tablets can improve the heart rate variability with safety and effectiveness.
作者
陈文霖
张晓芹
陈礼平
潘铨
徐文峥
CHEN Wenlin;ZHANG Xiaoqin;CHEN Liping;PAN Quan;XU Wenzheng
出处
《新中医》
CAS
2020年第23期36-38,共3页
New Chinese Medicine
基金
丽水市科技计划项目(2019ZDYF23)。
关键词
室性早搏
平心复脉合剂
琥珀酸美托洛尔缓释片
心率变异性
Premature ventricular contractions
Pingxin Fumai mixture
Metoprolol succinate sustained-release tablets
Heart rate variability
