摘要
目的:观察保肾降糖汤联合福辛普利钠片治疗早期糖尿病肾病的临床效果。方法:将2018年1月-2019年12月我院接诊的60例早期糖尿病肾病患者作为研究对象,采用随机数字表法将其分为对照组和研究组,对照组采用福辛普利钠片治疗,研究组采用保肾降糖汤联合福辛普利钠片治疗,对比两组患者治疗前后血脂、血糖和肾功能指标及治疗有效率的变化。结果:研究组的总有效率明显高于对照组,差异有统计学意义。治疗后研究组患者的糖化血红蛋白(Glycated Hemoglobin A1c,HbA1c)、血清胆固醇(Total Cholesterol,TC)、三酰甘油(Triacylglycerol,TG)、低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol,LDL-C)水平低于对照组,而高密度脂蛋白胆固醇(High Density Liptein Cholesterol,HDL-C)水平高于对照组,均P<0.05。研究组患者治疗后的空腹血糖(Glucose,GLU)、HbA1c、TC、TG、LDL-C水平较治疗前降低,而HDL-C水平较治疗前升高,均P<0.05;对照组患者治疗后的HbA1c、TC、TG、LDL-C水平较治疗前降低,差异均有统计学意义。治疗后研究组患者的24 h尿蛋白定量(24-hour Urine Protein Quantification,24 h UPQ)、尿微量清蛋白(Urinary Microalbumin,mAlB)、尿蛋白排泄率(Urinary Albumin Excretion Rate,UAER)水平低于对照组,而估算的肾小球滤过率(Estimated Glomerular Filtration Rate,eGFR)高于对照组,差异均有统计学意义。研究组和对照组患者均表现为治疗后的24 h尿蛋白定量、尿微量清蛋白、尿蛋白排泄率水平较本组治疗前降低,而肾小球滤过率较治疗前升高,均P<0.05。结论:保肾降糖汤联合福辛普利钠片治疗早期糖尿病肾病的临床疗效确切,可明显改善患者症状,在延缓病情进展及控制疾病恶化方面效果明显,值得临床推广应用。
Objective:To observe clinical effects of the Baoshen Jiangtang decoction(保肾降糖汤)with fosinopril sodium tablet on early diabetic nephropathy.Methods:60 cases were randomly divided into the control group and study group.The control group was treated with fosinopril sodium tablets,and the study group took the Baoshen Jiangtang decoction more.Results:The total efficiency in the study group was significantly higher,with a statistically significant difference.After treatment,the levels of HbA1c,TC,TG and LDL-C in the study group were lower.The levels of HDL-C in the study group were higher than the control group,P<0.05.The levels of GLU,HbA1c,TC,TG,and LDL-C in the groups were lower,and the HDL-C levels in the study group were higher than before treatment(P<0.05).After treatment,the 24-hour urine protein quantification,urine microalbumin,and urinary albumin excretion rate in groups were decreased,and those in the study group were lower than the control group,while the glomerular filtration rate in the groups was increased,and that in the study group was higher,with statistically significant differences(P<0.05).Conclusion:The Baoshen Jiangtang decoction with fosinopril sodium tablet show a definite clinical effect on early diabetic nephropathy,which can significantly improve the symptoms of patients,delay the progress of the disease,control the deterioration of the disease,and is worthy of clinical application.
出处
《中医临床研究》
2020年第32期54-57,共4页
Clinical Journal Of Chinese Medicine
基金
广东省中医药局科研课题(编号:20182189)。
关键词
保肾降糖汤
福辛普利钠片
早期糖尿病肾病
临床疗效
The Baoshen Jiangtang decoction
Fosinopril sodium tablet
Early diabetic nephropathy
Clinical effects
