摘要
肝细胞肝癌(HCC)最重要的治疗手段是根治性肝切除,影响患者术后生存的主要因素是较高的转移复发率。肝癌术后的转移复发是多种因素参与影响的复杂过程,涉及到机体、肿瘤组织和肿瘤微环境3个方面因素,包括机体免疫抑制、肿瘤血管的形成、细胞外基质降解等,但是其具体分子机制仍没有明确阐明。早期预测术后转移复发风险有助于进行及时有效的干预,改善患者预后。研究发现,多种生物标志物(如OPN、miRNA)能够有效监测肝癌术后的转移复发,从而尽早的为肝癌术后的治疗提供指导。本文就上述研究进行阐述,为肝癌术后的早期防治提供参考。
Hepatocellular hepatectomy is the most important treatment for primary liver cancer.However,the main factor affecting the survival of patients after operation is the high rate of metastasis and recurrence.Metastasis and recurrence of liver cancer after operation is a complicated process influenced by many factors,involving the body,tumor tissue and tumor microenvironment,immune suppression,formation of tumor vessels,degradation of extracellular matrix,etc.However,the specific molecular mechanism has not been clearly elucidated and more in-depth research is needed.Early prediction of the risk of postoperative metastasis and recurrence is helpful for timely and effective intervention to improve the prognosis of patients.Studies have found that various biomarkers(such as OPN and miRNA)can effectively monitor the metastasis and recurrence of liver cancer after operation,thus providing guidance for the treatment of liver cancer after operation as soon as possible.In this paper,the above research is described to provide reference for early prevention and treatment of liver cancer after operation.
作者
韩明
周军
魏海梁
陈志国
郭辉
Han Ming;Zhou Jun;Wei Hailiang;Chen Zhiguo;Guo Hui(Department of Traditional Chinese and Western Medicine,First Clinical Medical College,Shaanxi University of Traditional Chinese Medicine,Xianyang,712046,China;Department of General surgery,Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang,712046,China)
出处
《广西医科大学学报》
CAS
2020年第12期2288-2294,共7页
Journal of Guangxi Medical University
基金
国家自然科学基金资助项目(No.81904192)
咸阳市科技成果推广计划资助项目(No.2018KT-22)
咸阳市二0一八年科学技术研究计划项目(No.2018K02-100)。
关键词
肝癌
转移
复发
分子机制
生物标志物
hepatocellular carcinoma
transfer
recurrence
molecular mechanism
biomarkers
