摘要
慢性鼻-鼻窦炎(chronic rhinosinusitis,CRS)作为一种复杂的异质性疾病,分为不伴(CRS without nasal polyps,CRSs NP)或伴息肉(CRS with nasal polyps,CRSwNP)。其发病机制不清,黏膜屏障假说作为较为全面的假说,提出CRS的发病与鼻黏膜机械性和免疫屏障缺陷密不可分,体现了黏膜上皮的重要作用。本文主要围绕鼻黏膜上皮在CRSw NP发病中的作用进行综述,并以鼻黏膜上皮为靶点提出治疗展望。
Chronic rhinosinusitis as a complex heterogeneous disease is divided into CRS without nasal polyps or CRS with nasal polyps.Its pathogenesis is unclear,and the mucosal barrier hypothesis as a more comprehensive hypothesis suggests that the pathogenesis of CRS is inseparable from the mechanical and immune barrier defects of the nasal mucosa,reflecting the important role of mucosal epithelium.This article focuses on the role of nasal mucosal epithelium in the pathogenesis of CRSw NP,and proposes a therapeutic prospect with nasal mucosal epithelium as a target.
作者
刘江怡
廖敏
李双
毛弈友
陈卓
陈杰
杨玉成
LIU Jiangyi;LIAO Min;LI Shuang;MAO Yiyou;CHEN Zhuo;CHEN Jie;YANG Yucheng(Department of Otorhinolaryngology,the First Affiliated Hospital of Chongqing Medical University,Chongqing First Hospital,Chongqing Medical University,Chongqing 400016,China)
出处
《中国中西医结合耳鼻咽喉科杂志》
2020年第6期477-480,共4页
Chinese Journal of Otorhinolaryngology in Integrative Medicine
基金
国家自然科学基金项目(No:81970864)
重庆市中青年医学高端人才工作室项目[No:渝卫人(2018)2号]
重庆医科大学附属第一医院学术带头人储备人才基金项目[2019]
重庆市卫计委重点项目(2015HBRC004)
重庆市科委重点项目(cstc2015jcyjBX0047)
重庆市卫计委中医药项目(ZY201702070)。
关键词
慢性鼻窦炎
鼻息肉
上皮屏障
发病机制
治疗
Chronic rhinosinusitis
nasal polyps
epithelial barrier
pathogenesis
treatment
