摘要
目的探讨阿昔洛韦联合糖皮质激素治疗重度病毒性角膜炎的疗效。方法将110例重度病毒性角膜炎患者随机分为两组,每组各55例。对照组患者予以阿昔洛韦治疗,研究组患者予以阿昔洛韦联合糖皮质激素治疗。比较两组患者治疗后的临床症状、体征评分、临床疗效及随访12个月的复发率。结果研究组患者治疗后异物感为(0.64±0.12)分、疼痛为(0.62±0.14)分、流泪为(0.33±0.09)分、畏光为(0.42±0.05)分,明显低于对照组(1.14±0.35)分、(1.05±0.22)分、(0.94±0.24)分、(1.01±0.15)分,比较均有统计学意义(P<0.05)。研究组患者治疗后睫状充血为(0.51±0.17)分、角膜荧光素染色为(0.57±0.10)分、角膜基质水肿为(0.59±0.13)分、角膜上皮缺损为(0.67±0.13)分,明显低于对照组(1.19±0.49)分、(1.04±0.24)分、(1.06±0.33)分、(1.03±0.25)分,比较均有统计学意义(P<0.05)。研究组患者的有效率、复发率均明显优于对照组,比较有统计学意义(P<0.05)。结论单用阿昔洛韦治疗重度病毒性角膜炎的效果有限,联合糖皮质激素可显著提高临床疗效,降低复发率。
Objective To investigate the effi cacy of aciclovir combined with glucocorticoids in the treatment of severe viral keratitis.Methods One hundred and ten patients with severe viral keratitis were randomly divided into two groups:the control group received aciclovir treatment,and the study group received aciclovir combined with glucocorticoid treatment.The clinical symptom and sign scores,clinical effi cacy and recurrence rate of 12 months followup were compared between the two groups.Results After treatment,the scores of foreign body sensation(0.64±0.12),pain(0.62±0.14),tears(0.33±0.09)and photophobia(0.42±0.05)in the study group were signifi cantly lower than those in the control group(1.14±0.35),(1.05±0.22),(0.94±0.24)and(1.01±0.15),which were statistically signifi cant(P<0.05).After treatment,the scores of ciliary congestion(0.51±0.17),fl uorescein staining(0.57±0.10),stromal corneal edema(0.59±0.13)and corneal epithelial defect(0.67±0.13)in the study group were signifi cantly lower than those in the control group(1.19±0.49),(1.04±0.24),(1.06±0.33)and(1.03±0.25),which were statistically signifi cant(P<0.05).The eff ective rate and recurrence rate of patients in the study group were signifi cantly better than those in the control group,which was statistically signifi cant(P<0.05).Conclusion Aciclovir alone has a limited eff ect in the treatment of severe viral keratitis,while the combination of glucocorticoids can signifi cantly suggest clinical effi cacy and reduce the recurrence rate.
作者
李鹏
LI Peng(Department of Ophthalmology,Liaoning Provincial Mental Health Center,Tieling 112300,China)
出处
《中国医药指南》
2020年第34期99-100,共2页
Guide of China Medicine
