摘要
目的:探究补肾祛瘀针刺疗法加穴位注射治疗肺癌骨转移重度癌痛对5-HT、PGE2和ET-1水平的影响。方法:选取2017年2月—2019年12月我院收治的160名肺癌骨转移重度癌痛患者,按随机数字表法分为对照组和观察组,各80例。对照组行盐酸羟考酮缓释片口服治疗,观察组行补肾祛瘀针刺疗法加穴位注射治疗,两组均治疗4周。比较两组临床疗效及治疗期间不良反应发生率;比较两组治疗前后临床症状、疼痛、体力状况及QLQ-LC13评分变化;检测并比较两组血清5-HT、PGE2和ET-1水平差异。结果:观察组患者总有效率为92.50%(74/80),高于对照组的80.00%(64/80)(P <0.05);与治疗前比较,治疗后两组中医症候积分、NRS疼痛评分、QLQ-LC13评分(疲乏、咳嗽、食欲缺乏、胸痛、气促)及血清5-HT、PGE2和ET-1水平均降低,且观察组低于对照组(P <0.05);两组KPS评分升高,且观察组高于对照组(P <0.05);观察组不良反应发生率为7.50%(6/80),对照组不良反应发生率为5.00%(4/80),两组比较差异无统计学意义(P> 0.05)。结论:补肾祛瘀针刺疗法加穴位注射可降低肺癌骨转移重度癌痛患者血清5-HT、PGE2和ET-1水平,缓解患者临床症状及癌痛程度,提高患者生活质量,且未增加不良反应,安全性可靠。
Objective: To investigate the effects of Bushen Quyu Acupuncture combined with acupoint injection on the levels of 5-HT,PGE2 and ET-1 in the treatment of severe cancer pain due to lung cancer bone metastases. Methods: 160 patients met the inclusion criteria were randomly divided into the control group and the observation group,with 80 cases in each group. The control group was treated with Oral Oxycodone Hydrochloride Sustained-Release Tablets,and the observation group was treated with Bushen Quyu acupuncture combined with acupoint injection. The treatment duration was 4 weeks in the two groups. The clinical efficacy and the incidence of adverse reactions were compared between the two groups. The clinical symptoms,pain,physical condition,and QLQ-LC13 scores were compared between before and after the treatment in the two groups.The differences in serum levels of 5-HT,PGE2 and ET-1 were detected and compared between the two groups after the treatment. Results: The total effective rate was 92. 50%( 74/80) in the observation group,which was significantly higher than 80. 00%( 64/80) in the control group( P < 0. 05). The TCM symptom scores,NRS pain scores,QLQ-LC13 scores( fatigue,cough,poor appetite,chest pain,shortness of breath)and serum levels of 5-HT,PGE2 and ET-1 were all decreased after the treatment compared to those before the treatment in the two groups;of which the decreases in the observation group were more significant( P <0. 05). KPS scores were increased after the treatment compared to those before the treatment in the two groups;of which the increases in the observation group were more significant( P < 0. 05). In terms of the incidence of adverse reactions,it was 7. 50%( 6/80) in the observation group and 5. 00%( 4/80) in the control group,and there was no statistical difference between the two groups( P > 0. 05). Conclusion: Bushen Quyu acupuncture combined with acupoint injection can reduce the serum levels of 5-HT,PGE2 and ET-1 in patients with lung cancer bone metastases and severe cancer pain,it can alleviate clinical symptoms and cancer pain,improve the life quality of the patients,without increasing adverse reactions. The therapy is reliable and safe.
作者
吴盛
宋益青
张建军
王媛
钟欢
何艳霞
欧畅
WU Sheng;SONG Yiqing;ZHANG Jianjun;WANG Yuan;ZHONG Huan;HE Yanxia;OU Chang(Yongchuan District Hospital of Traditional Chinese Medicine,Chongqing 402160,China)
出处
《针灸临床杂志》
2020年第11期5-9,共5页
Journal of Clinical Acupuncture and Moxibustion
