摘要
目的系统评价益气养阴法治疗病毒性心肌炎的疗效和安全性。方法通过计算机检索PubMed、EMbase、the Cochrane Library、万方、中国知网及中国生物医学文献数据库(CBM)等数据库,并手动检索会议记录及灰色文献。检索时间从建库到2019年9月。收集所有益气养阴法治疗病毒性心肌炎的随机对照试验,对纳入的文献进行质量评价与资料提取,并采用RevMan 5.3进行Meta分析。结果共纳入15项研究,涉及1231例病人。治疗组临床总有效率优于对照组,差异有统计学意义[Z=7.77,OR=3.78,95%CI(2.70,5.29),P<0.00001];治疗组心电图期前收缩疗效优于对照组,差异有统计学意义[Z=4.25,OR=3.61,95%CI(2.00,6.52),P<0.00001];治疗组心脏射血分数高于对照组,差异有统计学意义[Z=6.76,MD=6.59,95%CI(4.68,8.50),P<0.00001]。漏斗图分析结果显示:两组临床疗效总有效率存在发表偏倚可能性较小。结论现有证据表明:益气养阴法治疗病毒性心肌炎可改善病人临床疗效及症状。
Objective To evaluate the efficacy and safety of tonifying qi and nourishing yin in the treatment of viral myocarditis.Methods PubMed,EMbase,the Cochrane Library,Chinese Biomedical Literature Database(CBM),China Journal Full-Text Database(CNKI),Wanfang database were searched.Meanwhile,relevant meeting and grey literature were searched manually from the establishment to September,2019.All randomized controlled trials in the treatment of viral myocarditis by tonifying qi and nourishing yin were collected.The included literatures were evaluated for literature quality and data extraction,and data statistics and analysis were conducted by RevMan 5.3.Results Fifteen studies were included eventually,involving 1231 patients.The results of meta-analysis showed that the total clinical efficacy of the treatment group was better than that of the control group[Z=7.77,OR=3.78,95%CI(2.70,5.29),P<0.00001],the effect of electrocardiogram extrasystole in treatment group was better than that in control group[Z=4.25,OR=3.61,95%CI(2.00,6.52),P<0.00001],and the cardiac ejection fraction of treatment group was higher than that of control group[Z=6.76,MD=6.59,95%CI(4.68,8.50),P<0.00001].Funnel plot analysis showed that the total clinical efficacy betweentwo groups was less biased.Conclusion Current evidence showed that tonifying qi and nourishing yin could obviously improve the clinical efficacy and symptoms of viral myocarditis.
作者
王琦
张楷钰
刘巍
杨建飞
王贺
周亚滨
WANG Qi;ZHANG Kaiyu;LIU Wei;YANG Jianfei;WANG He;ZHOU Yabin(Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China)
出处
《中西医结合心脑血管病杂志》
2020年第24期4126-4131,共6页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
国家自然科学基金项目(No.81102590)
黑龙江省中医药科研项目(No.ZHY16-002)
黑龙江省博士后基金项目(No.LBH-Z08007)。
关键词
病毒性心肌炎
益气养阴
随机对照试验
临床疗效
心电图期前收缩疗效
心脏射血分数
META分析
viral myocarditis
tonifying qi and nourishing yin
randomized controlled trials
clinical efficacy
the effect of electrocardiogram extrasystole
cardiac ejection fraction
Meta-analysis
