摘要
目的分析补肾逐瘀汤对肾虚血瘀型子宫内膜异位症术后预后及炎性因子的影响。方法选择2017年1月—2018年5月医院确诊治疗的子宫内膜异位症患者,按入排标准最终纳入68例患者作为研究对象,以数字随机表法均分到两组,对照组采用腹腔镜手术治疗;观察组采用手术联合补肾逐瘀汤治疗。比较两组临床治疗效果、对比两组治疗前后炎性因子、应激指标水平,并对痛经及中医症状进行积分比较。结果观察组总有效率94.12%(32/34)显著高于对照组总有效率73.53%(25/34)(P<0.05);两组经治疗后痛经评分及中医症候评分均显著降低(P<0.05);两组患者的IL-6、IL-8、TNF-α水平降低,且观察组显著低于对照组(P<0.05);经过治疗后,观察组的SOD和VitE水平显著高于对照组,ROS水平低于对照组(P<0.05);观察组应激指标水平显著优于对照组(P<0.05);在治疗后6个月,观察组痛经状况及中医症候评分仍优于对照组(P<0.05)。结论补肾逐瘀汤能明显改善肾虚血瘀型子宫内膜异位症患者炎性因子及应激指标水平,对改善患者临床症状及术后预后安全有效。
Objective To analyze the effect of Bushen Zhuyu Decoction on prognosis and inflammatory factors of endometriosis of kidney deficiency and blood stasis type after operation. Methods Sixty-eight patients with endometriosis diagnosed and treated in our hospital from 2017 to May 2018 were eventually included according to the inclusion criteria and exclusion criteria. They were divided into two groups by digital random table method. The control group was treated by laparoscopic surgery. The observation group was treated with Bushen Zhuyu Decoction. We compared the clinical effect of the two groups, the levels of inflammatory factors and stress indicators before and after treatment, and compared the scores of dysmenorrhea and TCM symptoms. Result The total effective rate of the observation group was 94.12%(32/34), which was significantly higher than that of the control group 73.53%(25/34)(P<0.05). After treatment, the levels of IL-6, IL-8 and TNF-α in the patients were significantly lower than those in the control group(P<0.05). After treatment, the dysmenorrhea score and TCM symptom score of the two groups were significantly reduced. Six months after treatment, the dysmenorrhea status and TCM symptoms of the observation group were significantly better than those of the control group(P<0.05). After treatment, the levels of SOD and VitE of the observation group were significantly higher than those of the control group, and the ROS levels were significantly lower than those of the control group. After treatment, the stress index level of the observation group was significantly better than that of the control group(P<0.05). Conclusion Bushen Zhuyu Decoction can significantly improve the levels of inflammatory factors and stress indicators in patients with endometriosis of kidney deficiency and blood stasis type. It is safe and effective, and has positive significance for improving the clinical symptoms and prognosis of patients after operation.
作者
徐广立
赵纪华
孙艳
王艳娜
卫爱武
XU Guangli;ZHAO Jihua;SUN Yan;WANG Yanna;WEI Aiwu(Reproductive Medicine Center,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,Henan,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第12期109-112,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81673735,82074167)
河南省中医药科学研究专项(2017JDZX002)。
关键词
补肾逐瘀汤
腹腔镜
子宫内膜异位症
炎性因子
Bushen Zhuyu Decoction
laparoscopy
endometriosis
inflammatory factors
