摘要
目的探讨橘红痰咳液联合孟鲁司特钠用于治疗小儿急性支气管炎的疗效及对IL-1β、sTREM-1和CysLTs水平影响。方法选取来医院接受治疗的80例急性支气管炎患儿,随机分为两组各40例。对照组患儿给予孟鲁司特钠,治疗组在对照组基础上口服橘红痰咳液,两组患儿均持续治疗10 d。对比两组患儿的临床疗效、临床症状消失时间、中医症候积分、血清炎性因子水平、sTREM-1和CysLTs水平及Ti/Te、RR、tPTEF/tE、VT水平。结果治疗后,治疗组总有效率较高(P<0.05);治疗组患儿咳嗽、咯痰、肺部体征、发热等症状消失时间显著低于对照组(P<0.05);两组患儿治疗前中医症候积分差异无统计学意义(P>0.05);两组患儿治疗后咳嗽、咯痰、肺部体征、发热等证候评分显著降低(P<0.05);并且治疗组降低较多(P<0.05);两组患儿治疗前IL-1β、TNF-α和hs-CRP水平差异无统计学意义(P>0.05);治疗后两组患儿IL-1β、TNF-α和hs-CRP水平显著降低(P<0.05);并且治疗组降低较多(P<0.05);两组患儿治疗前sTREM-1和CysLTs水平差异无统计学意义(P>0.05);两组患儿治疗后sTREM-1和CysLTs水平水平显著降低(P<0.05);并且治疗组降低较多(P<0.05);两组患儿治疗前Ti/Te、RR、tPTEF/tE、VT水平差异无统计学意义(P>0.05);两组患儿治疗后Ti/Te、RR明显降低, tPTEF/tE、VT明显升高(P<0.05);且治疗组改善程度较大(P<0.05)。结论采用橘红痰咳液联合孟鲁司特钠用于治疗小儿支气管炎具有较好的治疗效果,能够改善血清IL-1β、sTREM-1和CysLTs水平,安全性较高,值得在临床上推广应用。
Objective To investigate the effect of Juhong Tanke Liquid combined with montelustra in the treatment of acute bronchitis in children and its effect on levels of IL-1β, sTREM-1 and CysLTs. Methods Eighty cases of acute bronchitis were randomly divided into two groups, 40 cases in each. The children in the control group were given montelukast, and those in the experimental group were given Juhong Tanke Liquid on the basis of the control group. Both groups continued the treatment for 10 days. The clinical efficacy, clinical symptom disappearance time, TCM syndrome score, levels of sTREM-1 and CysLTs, levels of Ti/Te, RR, tPTEF/Te and VT of the two groups were compared. Results After treatment, the total effective rate of the experimental group was higher(P<0.05). The disappearance time of cough, sputum, pulmonary signs and fever in the experimental group was significantly shorter than that in the control group(P<0.05). There was no difference in TCM syndrome score between the two groups before treatment(P>0.05). After treatment, the scores of cough, sputum, pulmonary signs and fever were significantly decreased(P<0.05). And those of the experimental group decreased significantly(P<0.05). There was no difference in levels of IL-1β, TNF-α or hs-CRP between the two groups before treatment(P>0.05). After treatment, the levels of IL-1β, TNF-α and hs-CRP in the two groups were significantly decreased(P<0.05). And those of the experimental group decreased significantly(P<0.05). There was no difference in sTREM-1 or CysLTs between the two groups before treatment(P>0.05). Levels of sTREM-1 and CysLTs in the two groups were significantly decreased after treatment(P<0.05). And those of the experimental group decreased significantly(P<0.05). There was no significant difference in Ti/Te, RR, tPTEF/Te or VT between the two groups before treatment(P>0.05). After treatment, Ti/Te and RR were significantly decreased, while tPTEF/Te and VT were significantly increased(P<0.05). And those of the experimental group improved significantly(P<0.05). Conclusion The use of Juhong Tanke Liquid combined with montelukast in the treatment of pediatric bronchitis has a good therapeutic effect and can improve the serum levels of IL-1β, sTREM-1 and CysLTs with higher safety, worthy of clinical promotion and application.
作者
李才平
刘婧华
LI Caiping;LIU Jinghua(The Third Affiliated Hospital of Southern Medical University Pediatrics,Guangzhou 510630,Guangdong,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第12期248-252,共5页
Chinese Archives of Traditional Chinese Medicine
基金
广东省科技计划(2016ZC316)。
