期刊文献+

辛开苦降法治疗肠易激综合征Meta分析 被引量:6

Meta Analysis of Pungent Dispersing and Bitter Descending Method for Treating Irritable Bowel Syndrome
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摘要 目的:探讨辛开苦降法干预肠易激综合征(IBS)的有效性和安全性。方法:计算机检索中文期刊全文数据库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、PubMed等在线数据库,搜集辛开苦降法相关方剂治疗IBS的随机对照试验。检索时限从2006年1月1日至2020年5月7日。两位研究员按照纳入和排除标准独立进行文献筛选、提取数据,运用Cochrane协作网推荐的偏倚风险评价表对每个纳入试验进行偏倚风险和质量评估,并采用Revman 5.3软件进行系统评价与Meta分析。结果:共纳入25篇中文随机对照试验,合计1834例患者。结果显示,与西药对照组比较,单用辛开苦降法相关方剂或联合常规西药能提高IBS患者临床疗效(总有效率RR=1.27,95%CI为1.21~1.32,P<0.00001,治愈率RR=1.70,95%CI为1.45~2.00,P<0.00001),降低复发率(RR=0.35,95%CI为0.25~0.50,P<0.00001)。结论:辛开苦降法治疗IBS疗效优于常规西药治疗,可改善患者临床症状,降低复发率。但由于纳入研究文献存在一定发表偏倚且方法学有限,上述结论仍需开展大样本、高质量、多中心、双盲的随机对照试验进一步验证。 Objective:To explore the effectiveness and safety of pungent dispersing and bitter descending method for intervention of irritable bowel syndrome(IBS).Methods:Randomized controlled trials of related prescriptions of pungent dispersing and bitter descending method in the treatment of IBS were collected through China National Knowledge Internet(CNKI),Chinese Science and Technology Journal Database(VIP),Chinese Academic Journal Database(Wanfang Data),PubMed and other online databases.The time limit is from January 1,2006 to May 7,2020.Two researchers independently screened the literature and extracted data according to the inclusion and exclusion criteria,applied the Risk of Bias Evaluation Scale recommended by the Cochrane Collaboration to evaluate the risk of bias and quality of each included trials,and adopted Revman 5.3 software for systematic evaluation and Meta analysis.Results:A total of 25 randomized controlled trials in Chinese were included,with a total of 1834 patients.The results showed that compared with the western medicine control group,the pungent dispersing and bitter descending method alone or combined with conventional western medicine can improve the clinical efficacy of IBS patients(total effective rate RR=1.27,95%CI:1.21~1.32,P<0.00001;recovery rate RR=1.70,95%CI:1.45~2.00,P<0.00001)and reduce the recurrence rate(RR=0.35,95%CI:0.25~0.50,P<0.00001).Conclusions:The curative effect of pungent dispersing and bitter descending method on IBS is better than conventional western medicine,which can improve the clinical symptoms of patients and reduce the recurrence rate.However,due to the publication bias of the included research literature and the limited methodological quality,the above conclusions still need to be further verified by large-sample,high-quality,multi-center,double-blind randomized controlled trials.
作者 李一桐 王月娇 宋瑶 尤佳 汪红兵 LI Yitong;WANG Yuejiao;SONG Yao;YOU Jia;WANG Hongbing(Beijing University of Chinese Medicine,Beijing 100029,China;Capital Medical University,Beijing 100069,China;Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China)
出处 《山东中医药大学学报》 2021年第1期90-98,共9页 Journal of Shandong University of Traditional Chinese Medicine
基金 国家自然科学基金资助项目(编号:81774257)。
关键词 辛开苦降法 肠易激综合征 偏倚风险评价表 临床疗效 复发率 META分析 pungent dispersing and bitter descending method irritable bowel syndrome Risk of Bias Evaluation Scale clinical efficacy recovery rate Meta analysis
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