摘要
目的:观察针刺治疗椎动脉型颈椎病临床疗效,并探索血浆血栓素B2(thromboxane,TXB2)、6-酮-前列腺素F1α(6 keto prostaglandin F 1α,6-Keto-PGF1α)在椎动脉型颈椎病中的变化情况及意义。方法:将60例椎动脉型颈椎病患者按随机数字表法随机分为治疗组和对照组,每组各30例。治疗组以针刺及西药治疗,对照组以牵引及西药治疗。两组均在治疗前和治疗2周后观察椎动脉型颈椎病患者临床疗效、眩晕症状、功能积分量表变化情况及血浆TXB2、6-Keto-PGF1α的变化情况。结果:治疗2周后,两组临床疗效比较,治疗组有效率为96.6%,对照组有效率为90.0%。两组眩晕症状与功能积分比较,各项积分均较治疗前显著提高(P<0.05),且治疗组在颈肩痛、日常生活及工作方面改善更明显(P<0.05),治疗组总分较对照组明显提高(P<0.05)。两组治疗后较治疗前血浆TXB2含量下降,6-Keto-PGF1α含量明显上升,差异具有统计学意义(P<0.05);两组治疗后血浆TXB2含量比较,差异具有统计学意义(P<0.05),血浆6-Keto-PGF1α含量比较,差异无统计学意义(P>0.05)。结论:针刺能有效降低椎动脉型颈椎病患者血浆TXB2含量,升高血浆6-K-PGF1α的含量,通过纠正异常的血管舒缩功能发挥作用。
Objective:To observe the clinical efficacy of acupuncture in the treatment ofcervical spondylosis of vertebral artery type,and explore the changes and significance of plasma thromboxane B2(TXB2)and 6 keto prostaglandin F 1α(6-Keto-PGF1α)in cervical spondylosis of vertebral artery type.Methods:60 patients with cervical spondylosis of vertebral artery type were randomly divided into treatment group and control group according to the random number table method,with 30 cases in each group.The treatment group was treated with acupuncture and western medicine,and the control group was treated with traction and western medicine.Both groups were observed before treatment and after 2 weeks of treatment in patients with cervical spondylosis of vertebral artery type,clinical efficacy,vertigo symptoms and changes in functional scores,and changes in plasma TXB2 and 6-Keto-PGF1α.Results:Comparing the clinical efficacy of the two groups after 2 weeks of treatment,the effective rate of the treatment group was 96.6%,and the effective rate of the control group was 90%.After 2 weeks of treatment,the vertigo symptoms and function scores of the two groups showed that the classifications were improved compared with before treatment(P<0.05),and the treatment group had more obvious improvement in neck and shoulder pain,daily life and work(P<0.05),After 2 weeks of treatment,the total score of the treatment group was significantly higher than that of the control group(P<0.05).After 2 weeks of treatment,the plasma TXB2 content of the two groups decreased compared with before treatment,and the 6-Keto-PGF1αcontent increased significantly,and the difference was statistically significant(P<0.05).The difference in plasma TXB2 content between the two groups after 2 weeks of treatment was statistically significant(P<0.05),and the difference in plasma 6-Keto-PGF1αcontent was not statistically significant(P>0.05).Conclusion:Acupuncture can effectively reduce the plasma TXB2 content in patients with cervical spondylosis of vertebral artery type,increase the plasma 6-K-PGF1αcontent,and play a role by correcting the abnormal vasomotor function.
作者
梁永瑛
郭艳明
周帅亮
李德华
岑珏
LIANG Yongying;GUO Yanming;ZHOU Shualiang;LI Dehua;CEN Jue(Guanghua Hospital Affiliated to Shanghai University of Chinese Medicine,Shanghai China 200052)
出处
《中医学报》
CAS
2021年第1期202-206,共5页
Acta Chinese Medicine
基金
上海中医药大学预算内项目(2016YSN71)
第六批全国老中医药专家学术经验继承项目{国中医药人教发[2017]29号}。
