摘要
目的采用数据挖掘技术探究中医治疗银屑病的用药特点与规律,旨在为临床用药提供参考依据。方法收集我校第二附属医院皮肤科2017年12月~2019年12月的门诊系统记录,筛选符合要求的中药组方数据,构建银屑病方剂数据库,对银屑病方剂中的药物频次、功效及性味归经分布进行统计,运用MFP-tree算法进行关联规则分析。结果共收集664首方剂,涉及中药133味,涉及26种常用中药,可分为8类;使用频次排列前10位的药物分别是茯苓、甘草、土茯苓、黄芩、赤芍、白花蛇舌草、山药、金银花、白鲜皮、防风;使用频次排列前4位的中药类别为清热药、解表药、补虚药、利水渗湿药;药物的性味中苦味、甘味、寒味较多;多集中在肝经、心经、肺经,其次是脾经、胃经;共得到药对关联规则22条,3味药组关联规则20条,其中置信度前3位的药对分别为荆芥→防风、防风→黄芩、荆芥→黄芩,置信度前3位的3味药组分别为黄芩+白花蛇舌草→茯苓、甘草+黄芩→茯苓、防风+荆芥→黄芩。结论中医治疗银屑病以清热解毒、活血凉血为主,药物多归肝经、心经、肺经,符合中医药治疗银屑病的理论基础。基于数据挖掘技术分析银屑病组方用药规律,可为临床辨治银屑病提供参考。
Objective To observe the characteristics and rules of TCM treatment of psoriasis so as to provide references for clinical medication.Methods Collect the records of the outpatient system of the Dermatology Department of the Second Affiliated Hospital of our school from December 2017 to December 2019,screen out the data of Chinese medicine prescriptions that meet the requirements,and build a database of psoriasis prescriptions.The frequency,efficacy and distribution of the meridian distribution of the drugs in the prescriptions for psoriasis were counted,and the association rules were analyzed using the MFP-tree algorithm.Results A total of 664 prescriptions were selected and analyzed,including 133 different herbs with 26 of them more commonly used under 8 groups of efficacies.The top 10 herbs of frequencies were Poria,Licorice,RhizomaSmilacisGlabrae,Radix Scutellariae,Radix PaeoniaeRubra,HedyotidisDiffusae,RhizomaDioscoreae,FlosLonicerae,Cortex Dictamni,and Radix Saposhnikoviae.The top 4 main efficacies used were for heat-clearing,relieving exterior,replenishment of deficiency,and clearing damp and promoting diuresis.The natures and flavors of herbs were mostly bitter,sweet,and cold mostly concentrated in liver,heart,and lung meridians,followed by the spleen and stomach meridians.The association rule analysis showed a total of 22 rules of two-herb combinations and 20 rules of trigeminy combinations.The top two-herb combinations were HerbaSchizonepetae→Radix Saposhnikoviae,Radix Saposhnikoviae→Radix Scutellariae,HerbaSchizonepetae→Radix Scutellariae.The top trigeminy medications were Radix Scutellariae+Hedyotidis Diffusae→Poria,licorice+Radix Scutellariae→Poria,Radix Saposhnikoviae+Herba Schizonepetae→Radix Scutellariae.Conclusion TCM treatment of psoriasis mainly focuses on clearing heat and detoxification,promoting blood circulation and cooling the blood.The herbs mostly belong to the liver meridian,heart meridian and lung meridian consistent with the theoretical treatment of psoriasis.The rules of medication analyzed by data mining technology have great value for reference in clinical medication in treatment of psoriasis.
作者
李小智
丁长松
黄辛迪
LI Xiao-zhi;DING Chang-song;HUANG Xin-di(School of Information Science and Engineering,Hunan University of Chinese Medicine,Changsha 410208,Hunan,China)
出处
《医学信息》
2021年第1期4-6,14,共4页
Journal of Medical Information
基金
国家重点研发计划(编号:2017YFC1703306)
湖南省自然科学基金(编号:2018JJ2301)
湖南中医药大学计算机科学与技术学科开放基金(编号:2018JK03)。
