摘要
目的:探讨苦参汤联合湿润烧伤膏对急性肛裂患者中医证候积分、肛门水肿评分的影响。方法:选取2018年5月至2019年10月东南大学附属中大医院江北院区收治的急性肛裂患者114例,以随机数字表法将其分为观察组(n=57)和对照组(n=57)。对照组患者仅给予湿润烧伤膏治疗,观察组患者在对照组的基础上加用苦参汤治疗。观察两组患者的临床疗效,并比较中医证候积分、各症状缓解时间及肛门水肿评分的差异。结果:观察组患者的总有效率为94.74%(54/57),明显较对照组的80.70%(46/57)更高,差异有统计学意义(P<0.05)。治疗后,两组患者中医证候积分的主症积分、次症积分及总分明显低于治疗前,且观察组患者明显低于对照组,差异均有统计学意义(P<0.05)。观察组患者疼痛缓解时间、便秘缓解时间、出血消失时间及肛裂愈合时间明显较对照组缩短,差异均有统计学意义(P<0.05)。治疗后,两组患者肛门水肿评分较治疗前明显降低,且观察组患者较对照组明显降低,差异均有统计学意义(P<0.05)。结论:对急性肛裂患者采用苦参汤联合湿润烧伤膏治疗可降低其中医证候积分,促使各临床症状快速缓解,减轻肛门水肿程度,疗效肯定。
OBJECTIVE:To probe into the effects of Kushen decoction combined with moisture exposed burn ointment(MEBO)on traditional Chinese medicine(TCM)syndrome integral and anal edema score in patients with acute anal fissure.METHODS:Totally 114 patients with acute anal fissure admitted into Jiangbei Branch of Zhongda Hospital Affiliated to Southeast University from May 2018 to Oct.2019 were selected and divided into observation group and control group via random number table,with 57 cases in each group.The control group was treated with MEBO alone,while the observation group was given Kushen decoction based on the observation group.The clinical efficacy of two groups were observed,differences in TCM syndrome integral,remission time of symptoms and anal edema score were compared between two groups.RESULTS:The total effective rate of observation group was 94.74%(54/57),which was significantly higher than that of the control group(80.70%,46/57),with statistically significant difference(P<0.05).After treatment,the primary symptom score,secondary symptom score and total score of TCM syndrome integral of both groups were significantly lower than those of before treatment,and those of the observation group were significantly lower than the control group,with statistically significant differences(P<0.05).The remission time of pain and constipation,disappearance time of hemorrhage and recovery time of anal fissure of observation group were significantly shorter than those of the control group,with statistically significant differences(P<0.05).After treatment,the anal edema scores of both groups were significantly lower than those of before treatment,and that of the observation group was significantly lower than the control group,with statistically significant differences(P<0.05).CONCLUSIONS:The application of Kushen decoction combined with MEBO in the treatment of acute anal fissure can significantly reduce TCM syndrome integral,promote rapid relief of various clinical symptoms,alleviate anal edema,and the effect is worthy of recognition.
作者
陈艳妮
侯孝涛
沈伟
陈浩
张波
CHEN Yanni;HOU Xiaotao;SHEN Wei;CHEN Hao;ZHANG Bo(Dept.of Anorectal,Jiangbei Branch of Zhongda Hospital Affiliated to Southeast University,Jiangsu Nanjing 210043,China;Dept.of Anorectal,Zhongda Hospital Affiliated to Southeast University,Jiangsu Nanjing 210000,China)
出处
《中国医院用药评价与分析》
2020年第12期1421-1423,1428,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
江苏省自然科学基金项目(No.BK20171078)。
关键词
苦参汤
湿润烧伤膏
急性肛裂
中医证候积分
肛门水肿评分
Kushen decoction
Moisture exposed burn ointment
Acute anal fissure
TCM syndrome integral
Anal edema score
