摘要
目的探讨D二聚体(D-D)及炎性因子检测在慢性荨麻疹患者中的诊断价值。方法以70例慢性荨麻疹患者为对象,以同期70例健康人群为对照组。检测D-D、肿瘤坏死因子-α(TNF-α)、血清白介素-6(IL-6)水平,分析三者诊断慢性荨麻疹的价值。结果观察组D-D、TNF-α、IL-6水平高于对照组(P<0.05)。D-D诊断慢性荨麻疹的曲线下面积(AUC)、敏感度、特异性、最佳截断点分别为0.822(95%CI:0.749~0.882)、98.57%、70.00%、0.44 mg/L;TNF-α诊断慢性荨麻疹的AUC、敏感度、特异性、最佳截断点分别为0.803(95%CI:0.728~0.866)、90.00%、67.14%、10.76 ng/L;IL-6诊断慢性荨麻疹的AUC、敏感度、特异性、最佳截断点分别为0.817(95%CI:0.743~0.877)、74.29%、78.57%、10.65 pg/mL;D-D、TNF-α、IL-6联合检测诊断慢性荨麻疹的AUC、敏感度、特异性、最佳截断点、最大约登指数分别为0.960(95%CI:0.913~0.986)、87.14%、92.86%、0.58。结论D-D、TNF-α、IL-6在慢性荨麻疹患者中水平升高,检测三者水平有助于慢性荨麻疹的早期诊断。
Objective To investigate the diagnostic value of D-Dimer(D-D)and inflammatory factors in patients with chronic urticaria.Methods 70 patients with chronic urticaria were selected as the objects,and 70 healthy people as the control group.The levels of D-D,tumor necrosis factor-α(TNF-α)and serum interleukin-6(IL-6)were detected to analyze the value of the three in the diagnosis of chronic urticaria.Results The levels of D-D,TNF-αand IL-6 in the observation group were higher than those in the control group(P<0.05).The area under the curve(AUC),sensitivity,specificity and best cut-off point of D-D in the diagnosis of chronic urticaria were 0.822(95%CI:0.749-0.882),98.57%,70.00%,0.44 mg/L;AUC,sensitivity,specificity and best cutoff point of TNF-αin the diagnosis of chronic urticaria were 0.803(95%CI:0.728-0.866),90.00%,67.14%and 10.76,respectively The AUC,sensitivity,specificity and best cutoff point of IL-6 in the diagnosis of chronic urticaria were 0.817(95%CI:0.743-0.877),74.29%,78.57%,10.65 pg/ml;the AUC,sensitivity,specificity,optimal cutoff point and maximum yoden index of combined detection of D-D,TNF-αand IL-6 were 0.960(95%CI:0.913-0.986),87.14%,92.86%and 0.58,respectively.Conclusion The levels of D-D,TNF-αand IL-6 are increased in patients with chronic urticaria.Detection of the levels of D-D,TNF-αand IL-6 is helpful for the early diagnosis of chronic urticaria.
作者
吴桂菊
赵莹
侯强
WU Gui-ju;ZHAO Ying;HOU Qiang(The Dahua Hospital of Xuhui District,Shanghai,200231,China)
出处
《血栓与止血学》
2021年第2期206-208,共3页
Chinese Journal of Thrombosis and Hemostasis
关键词
D二聚体
炎性因子
慢性荨麻疹
D-dimer
Inflammatory factor
Chronic urticaria
