摘要
C—N键广泛存在于有机小分子、生物大分子及药物分子中.芳香胺是天然产物和药物分子之中的重要结构单元,通过对芳香胺芳基C—N键的断裂实现其催化转化,可作为药物分子后期修饰的重要手段.我们在此综述了过渡金属催化的芳香胺中性芳基C—N键断裂转化反应的最新研究进展,并对芳香胺芳基C—N键活化的发展趋势进行了展望.
The C—N bond exists in many organic molecules,biomacromolecules and drug molecules.The anilines are ubiquitous core structures of natural products and active pharmaceutical ingredients.Therefore,the catalytic transformations via cleavage of C—N bond in anilines may be used as an important means for the late stage modification of drug molecules.This review intends to give a introduction of recent progresses on transformations of aromatic amines via neutral C—N bond cleavage.
作者
张正兵
夏纪宝
ZHANG Zheng-bing;XIA Ji-bao(State Key Laboratory for Oxo Synthesis and Selective Oxidation,Center for Excellence in Molecular Synthesis,Suzhou Research Institute of LICP,Lanzhou Institute of Chemical Physics(LICP),Chinese Academy of Sciences,Lanzhou 730000,China;University of Chinese Academy of Sciences,Beijing 100049 China)
出处
《分子催化》
EI
CAS
CSCD
北大核心
2020年第6期569-578,I0003,共11页
Journal of Molecular Catalysis(China)
关键词
过渡金属
芳香胺
C—N键断裂
催化转化
transition-metal
aromatic amines
C—N bond cleavage
catalytic transformations
