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去铁胺在蛛网膜下腔出血中的治疗作用:来自动物实验的证据 被引量:1

Therapeutic effect of deferoxamine on subarachnoid hemorrhage: evidence from animal experiments
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摘要 蛛网膜下腔出血(subarachnoid hemorrhage,SAH)是临床常见的脑血管病之一,致残和致死率均较高,且患者大多转归不良。来自动物实验的研究表明,去铁胺可通过抗氧化应激、减轻炎症反应、改善脑水肿和减少神经细胞凋亡等途径发挥神经保护作用。文章对去铁胺在SAH后的神经保护作用及其机制进行了综述。 Subarachnoid hemorrhage(SAH)is one of the common clinical cerebrovascular diseases,with higher morbidity and mortality,and most patients have poor outcomes.Studies from animal experiments have shown that deferoxamine can play a neuroprotective effect through anti-oxidative stress,alleviating inflammatory response,improving brain edema,and reducing nerve cell apoptosis.This article reviews the neuroprotective effect and its mechanism of deferoxamine after SAH.
作者 刘壮华 陈军辉 王玉海 Liu Zhuanghua;Chen Junhui;Wang Yuhai(Department of Neurosurgery,the 904th Hospital of Joint Logistics Support Force of PLA,Wuxi Clinical College of Anhui Medical University,Wuxi 214004,China)
出处 《国际脑血管病杂志》 2020年第11期863-867,共5页 International Journal of Cerebrovascular Diseases
基金 无锡市科技发展基金(WX18IIAN04) 全军重点课题(15DX003)。
关键词 蛛网膜下腔出血 去铁胺 脑损伤 神经保护药 疾病模型 动物 Subarachnoid hemorrhage Deferoxamine Brain injuries Neuroprotective agents Disease models,animal
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