摘要
目的观察灸药联合治疗糖尿病肾病Ⅲ期的临床疗效及对炎症细胞因子的影响。方法选择糖尿病肾病Ⅲ期患者96例,随机分为对照组和观察组。对照组接受缬沙坦胶囊口服,观察组在对照组的基础上加用艾灸《神应经》治水四穴及口服升阳祛浊通络方。治疗前后进行肾损害相关指标和相关炎症因子的检测,并比较两组临床疗效。结果治疗后,观察组中医症状积分、空腹血糖(FBG)、血胆固醇(TC)、尿β2-微球蛋白(尿β2-MG)、尿白蛋白排泄率(UAER)、血肌酐(SCr)、尿素氮(BUN)、超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)明显低于对照组,差异均有统计学意义(P<0.05);治疗后,两组在收缩压(SBP)、舒张压(DBP)方面比较差异无统计学意义(P>0.05)。观察组总有效率与对照组比较差异具有统计学意义(P<0.05)。结论灸药联合治疗糖尿病肾病Ⅲ期疗效显著,可有效降低尿β2-MG、UAER、SCr、BUN水平,改善糖尿病肾病Ⅲ期患者体内微炎症状态,有效保护糖尿病肾病Ⅲ期患者的肾小球,延缓糖尿病肾病进展。
Objective To observe the clinical efficacy of moxibustion plus medication in treating diabetic nephropathy(DN)phaseⅢand its effects on inflammatory cytokines.Method A total of 96 patients with phaseⅢDN were recruited and randomized into a control group and an observation group.The control group was treated with Valsartan capsules,while the observation group was given additional moxibustion at the four acupoints specifically for water-related diseases recorded in Shen Ying Jing(Miraculous Effective Classic of Acupuncture)and oral Shengyang Quzhuo Tongluo decoction.The nephropathy-related parameters and relevant inflammatory cytokines were detected before and after treatment,and the clinical efficacy was observed between the two groups.Result After treatment,the symptom score of traditional Chinese medicine(TCM),fasting blood glucose(FBG),blood total cholesterol(TC),urineβ2-microglobin(β2-MG),urinary albumin excretion rate(UAER),serum creatinine(SCr),blood urea nitrogen(BUN),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor(TNF)-a and interleukin(IL)-6 were lower in the observation group than in the control group,and the differences were statistically significant(P<0.05);there were no significant between-group differences in the systolic blood pressure(SBP)and diastolic blood pressure(DBP)after treatment(P>0.05).The total effective rate in the observation group was significantly different from that in the control group(P<0.05).Conclusion Moxibustion plus medication can produce significant efficacy in treating DP;it can effectively down-regulate the levels of urineβ2-MG,UAER,SCr and BUN,improve the microinflammatory state and protect the glomerulus in patients with phaseⅢDN,and delay the progression of DN.
作者
王震宇
袁玲
高超
邢秀玲
康花民
WANG Zhen-yu;YUAN Ling;GAO Chao;XING Xiu-ling;KANG Hua-min(Tangshan Hospital of Traditional Chinese Medicine,Tangshan 063000,China;Tangshan Workers Hospital,Tangshan 063000,China;Kailuan General Hospital Zhaogezhuang Hospital,Tangshan 063101,China;Tangshan Maternal and Child Health Hospital,Tangshan 063000,China;North China University of Science and Technology Affiliated Hospital,Tangshan 063000,China)
出处
《上海针灸杂志》
2021年第1期16-20,共5页
Shanghai Journal of Acupuncture and Moxibustion
基金
河北省中医药管理局中医药类科研计划课题(2019206)。
关键词
灸法
治水四穴
《神应经》
糖尿病肾病
炎性细胞因子
Moxibustion
Four acupoints for water-related diseases
Shen Ying Jing
Diabetic nephropathies
Inflammatory cytokines
