摘要
六型分泌系统(type VI secretion system,T6SS)作为一种广泛存在于革兰氏阴性细菌中的可收缩纳米装置,通过将有毒物质,即效应因子(effector)注射于真核或原核细胞体内,杀死真核捕食者或原核竞争对手.近年来,T6SS基因的多样性、纳米装置的组装和效应因子的致病机制等都获得了广泛关注,取得了重大的突破.本综述基于T6SS的基因组成、组件装配、效应因子种类和调节机制等,分析总结T6SS基因组成的多样性,不同元件组装机制和对应的结构基础,效应因子种类和致病机理,以及T6SS复杂的调控网络等方面的研究进展和未解决的问题,以期为T6SS的研究提供参考.
The type VI secretion system(T6 SS)is a nanoscale contractile device,which is widely found in the gram negative bacteria.This machine can kill eukaryotic predators or prokaryotic competitors by injecting toxic effectors into target cells.In the past decades,the diversity of T6 SS gene clusters,the assembly of the T6 SS,and the infection mechanism of the effectors have been investigated extendedly,making great progress.This review summarizes the knowledge of the T6 SS from four aspects,including the composition and diversity of the T6 SS gene clusters,the structure and assembly of the T6 SS machine,the type of the effector,as well as the regulation network to provide insights for further T6 SS research.
作者
孔天翔
赵依昕
杜婧
李颖杰
KONG Tian-Xiang;ZHAO Yi-Xin;DU Jing;LI Ying-Jie(Tianshan College,Shandong University,Jinan 250100,China;College of Life Sciences,Shandong University,Qingdao 266237,China;State Key Laboratory of Microbial Technology,Shandong University,Qingdao 266237,China)
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2020年第12期1273-1284,共12页
Progress In Biochemistry and Biophysics
基金
山东大学基本科研业务费专项资金项目
青岛市应用基础研究计划项目青年专项(18-2-2-60-jch)资助。
