摘要
目的探讨炔雌醇环丙孕酮与左炔诺孕酮宫内缓释系统(LNG-IUS)治疗围绝经期异常子宫出血的临床效果。方法选取我院2016年5月~2017年5月收治的围绝经期异常子宫出血患者64例,根据随机数字表法分为药物组和IUS组,每组各32例。药物组患者口服炔雌醇环丙孕酮片,IUS组患者子宫内放置LNG-IUS。比较两组患者的临床疗效、月经量和血红蛋白含量。结果两组患者的临床效果比较,差异无统计学意义(P> 0.05)。治疗前两组患者的PBAC评分和Hb评分比较,差异无统计学意义(P> 0.05),治疗后,IUS组IUS评分显著低于药物组,IUS组Hb含量显著高于对照组,差异有统计学意义(P <0.05)。结论炔雌醇环丙孕酮和LNG-IUS治疗围绝经期异常临床效果明显,但相比于炔雌醇环丙孕酮,LNG-IUS改善月经量、血红蛋白效果更显著,且使用方便,更利于临床推广和使用。
Objective To investigate the clinical efficacy of ethinylestradiol and cyproterone acetate and levonorgestrel intrauterine system(LNG-IUS) on perimenopausal abnormal uterine hemorrhage. Methods In this research, a total of 64 patients with perimenopausal abnormal uterine hemorrhage admitted to our hospital from May 2016 to May 2017 were selected and divided into the drug group(n=32) and the IUS group(n=32) according to the random number table method. Patients in the drug group were given ethinylestradiol and cyproterone acetate tablets orally, while patients in the IUS group were placed LNG-IUS in uterus. The clinical efficacy, menstrual volume and hemoglobin content of the two groups were compared. Results There was no significant difference in clinical efficacy between the two groups(P > 0.05). Before treatment, there were no significant differences in PBAC score and Hb score between the two groups(P > 0.05). After treatment, IUS score in the IUS group was significantly lower than that in the drug group, Hb content in the IUS group was significantly higher than that in the control group, and the differences were statistically significant(P < 0.05). Conclusion Clinical efficacy of ethinylestradiol and cyproterone acetate and LNG-IUS on perimenopausal abnormality is obvious. However, compared with ethinylestradiol and cyproterone acetate, LNG-IUS is more effective in improving menstrual volume and hemoglobin, and is more convenient to use, which is more conducive to clinical promotion and application.
作者
孙苗
SUN Miao(The People's Hospital of Sixian,Anhui Province,Anhui,Sixian 234000,China)
出处
《中国医药科学》
2020年第23期151-153,共3页
China Medicine And Pharmacy
关键词
炔雌醇环丙孕酮
左炔诺孕酮宫内缓释系统
围绝经期
异常子宫出血
Ethinylestradiol and cyproterone acetate
Levonorgestrel intrauterine system
Perimenopausal period
Abnormal uterine hemorrhage
