摘要
目的:综述网络药理学方法在中药复方研究中的应用进展,为中药复方现代化研究提供参考与借鉴。方法:以"网络药理学""中药复方"为关键词,在中国知网、万方数据以及维普网等数据库中组合查询2006年5月-2020年5月发表的文献,筛选文献,对其所用数据库、分析平台、软件进行统计汇总;在进行计量分析的基础上,对网络药理学在中药复方研究中的应用情况进行归纳。结果与结论:共纳入有效文献761篇,其中2019年可检索到的文献数量高达313篇;在中药复方现代化研究中,网络药理学方法主要应用于中药复方作用机制、药效物质基础、配伍规律、复方优化以及"效-毒"网络等领域;常用的数据库及平台有中药信息数据库(中药系统药理数据库与分析平台和中药综合数据库)、疾病靶点数据库(TTD、OMIM)、药物靶点数据库及靶点预测平台(Drugbank、SwissTargetPrediction、TargetNet、PharmMapper)、网络药理学分析及预测软件/平台(CytoScape)等。网络药理学方法在中药复方研究领域中的应用较多,为其现代化研究提供了新的思路与方法。今后学者在开展相关研究时可结合药动学参数、活性化合物药效以及相关基础实验,采用加权的方法进行网络药理学分析,并注意整合多个数据库的信息以提高研究结果的科学性。
OBJECTIVE:To comprehensively evaluate the application progress of network pharmacology methods in TCM compound prescription research,and to provide reference for modernization of TCM compound prescription research.METHODS:Taking"network pharmacology"and"TCM compound prescription"as keywords,the literatures were retrieved from CNKI,Wanfang database and VIP during May 2006 to May 2020.Screening literature,the databases,analysis platforms,and software used of the literature were summarized;on the basis of quantitative analysis,the application of network pharmacology in the research of traditional Chinese medicine compound were summarized.RESULTS&CONCLUSIONS:There were a total of 761 valid literatures,among which the number of literatures that could be retrieved in 2019 reached 313.In the modernization research of TCM compound prescription,network pharmacology methods were mainly usedmechanism,material basis of pharmacodynamics,compatibility law,compound optimization,and"effect-toxic"network.Commonly used databasesand platforms included traditional chinese medicine information database(TCMSP and TCMID),therapeutic target database(TTD,OMIM),drug targets and target prediction platform(Drugbank,SwissTargetPrediction,TargetNet,PharmMapper),network pharmacology analysis and prediction software and platform(CytoScape),etc.Network pharmacology method was widely used in the field of TCM compound prescription research,and provided new ideas and methods for the modernization of TCM compound prescription research.In the future,the related research can be combined with the pharmacokinetic parameters,the efficacy of active compounds and related basic experiments,use the weighted method to carry out network pharmacology analysis,and integrate the information of multiple databases to improve the scientificity of research results.
作者
李秀云
章新友
吴地尧
潘树茂
丁亮
刘梦玲
LI Xiuyun;ZHANG Xinyou;WU Diyao;PAN Shumao;DING Liang;LIU Mengling(School of Pharmacy,Jiangxi University of TCM,Nanchang 330004,China;Evidence-based Medicine Center,Jiangxi University of TCM,Nanchang 330004,China;School of Computing,Jiangxi University of TCM,Nanchang 330004,China)
出处
《中国药房》
CAS
北大核心
2021年第2期182-189,共8页
China Pharmacy
基金
国家自然科学基金资助项目(No.81660727)。
关键词
中药复方
网络药理学
数据库
研究领域
应用
文献分析
TCM compound prescription
Network pharmacology
Database
Research field
Application
Literature analysis
