摘要
目的探讨正目的簇集素(CLU)基因多态性与非痴呆型血管性认知障碍(VCIND)之间的相关性。方法收集VCIND患者42例纳入VCIND组,认知正常者23例纳入认知正常组,记录人口学资料、危险因素、现病史、既往史,进行神经系统查体、神经心理学量表评分及磁共振成像检查,检测和分析两组CLU基因rs11136000snp、rs93311888snp位点,比较CLU基因多态性与VCIND患者及其影像学之间的相关性。结果(1)VCIND组与认知正常组的rs11136000snp位点比较,差异有统计学意义(P<0.05)。rs9331888snp位点比较无显著差异(P>0.05)。(2)VCIND组与认知正常组脑小血管病(SVD)总分对比差异有统计学意义(P<0.05)。(3)CLU基因多态性与VCIND患者的影像学比较差异有统计学意义(P<0.05)。结论CLU基因多态性与VCIND具有相关性;CLU基因的两个snp位点均与VCIND患者的影像学存在交互作用。
Objective To investigate the correlation between CLU gene polymorphism and VCIND.Methods 42 patients in VCIND study group and 23 patients in cognitive control group were collected.Demographic data,risk factors,history of present illness and previous history were recorded.The rs11136000 snp and rs93311888 snp of two groups of CLU genes were detected and analyzed,and the correlation between CLU gene polymorphism and VCIND patients and their imaging was compared.Results The comparison of RS11136000 snp sites between the VCIND group and the cognitive normal group showed statistical significance,while there was no significant difference on rs9331888 snp sites.The SVD total score of the VCIND group was significantly higher than that of the cognitive normal group(P<0.05).There was relationship between CLU gene polymorphism and VCIND patients imaging(P<0.05).Conclusions CLU gene polymorphism is correlated with VCIND.The two snp loci of CLU gene interact with the imaging of patients with VCIND.
作者
蒋子贺
尹昌浩
朱晓峰
JIANG Zi-He;YIN Chang-Hao;ZHU Xiao-Feng(Mudanjiang Medical University,Mudanjiang 157000,Heilongjiang,China)
出处
《中国老年学杂志》
CAS
北大核心
2021年第3期471-476,共6页
Chinese Journal of Gerontology
基金
国家自然科学基金项目(81771795)
黑龙江省省属高等学校基本科研业务费科研项目(2018-KYYWFMY-0002)
牡丹江医学院2018年度研究生创新科研项目(2018YJSCX-08MY)。
关键词
CLU基因多态性
非痴呆型血管认知障碍
磁共振成像
交互作用
CLU gene polymorphism
Non-dementia vascular cognitive impairment
Magnetic resonance imaging
Interaction
